Cancer studies
A Cohort study of co-morbid conditions and risk of chemotherapy associated febrile neutropenia in patients with selected types of cancers in Kaiser Permanente Southern California
The goal of this study is to examine the association between chronic co-morbid conditions and risk of febrile neutropenia, and grade III and IV neutropenia associated with first cycle chemotherapy.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
Amgen, Inc.Funding Years:
2013 - 2016Research Categories:
CancerA Registry to Improve Care and Research in Lung Cancer Screening
This is an award to demonstrate the feasibility of developing a registry of individuals who undergo lung cancer screening with low-dose CT.
Principal Investigator:
Michael K. Gould, MD, MSFunding Source:
Cancer Research Network (CRN)Funding Years:
2014 - 2016Adverse Health Outcomes in Breast Cancer Survivors exposed to Pain Medications
The aim of this longitudinal cohort study is to evaluate the comparative safety and risk of opioids and psychotropic drugs in women with breast cancer who suffer from chronic pain due to cancer or its treatments.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
California Breast Cancer Research Program (CBCRP)Funding Years:
2020 - 2023An Examination of Chronic Health Problems of Survivors of Cancer
An Examination of Chronic Health Problems of Survivors of Cancer
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
City Of HopeFunding Years:
2014 - 2016Research Categories:
CancerAntidepressants and Breast Cancer Pharmacoepidemiology
This study examines drug interactions between tamoxifen and antidepressants in nearly 23,000 breast cancer survivors diagnosed with early stage disease in the two largest health plans in California.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2010 - 2014Biobehavioral Vulnerability to Accelerated Aging in Breast Cancer Survivors
The aim of this project is to examine cellular and genomic markers of inflammation, telomere erosion, telomere length, and microarray data of 300 breast cancer survivors and comparison women who are enrolled in the KPSC-UCLA collaborative STRIVE1 and STRIVE2 studies.
Site Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
American Cancer SocietyFunding Years:
2016 - 2019Breast cancer screening decisions in younger women: a hybrid effectiveness-implementation study
The major goals of the project are to evaluate the effectiveness of a web-based decision aid on improving knowledge about breast cancer screening in women age 40 to 49 and reducing decisional conflict about breast cancer screening, and to explore the acceptability and feasibility of large-scale implementation.
Principal Investigator:
Erin E. Hahn, PhD, MPHFunding Source:
Natl Cancer InstFunding Years:
2017Cardiovascular toxicity following aromatase inhibitor use
The aim of this cohort is to assess the risk of cardiovascular disease associated with endocrine treatments for breast cancer.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
California Breast Cancer Research Program (CBCRP)Funding Years:
2013 - 2017Characterizing patients with HER2 breast cancer who relapse after HER2 directed adjuvant treatment
To understand real world outcomes in patients with invasive stage breast cancer who receive HER2-directed adjuvant treatment.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
Puma Biotechnology, Inc.Funding Years:
2020 - 2022Research Categories:
CancerChemotherapy Induced Compliances: FN risk in selected regimens
The goal of this observational study is to evaluate the average risk of febrile neutropenia (FN) in patients receiving chemotherapy regimens with previously undefined FN risk.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
Amgen, Inc.Funding Years:
2014 - 2016Research Categories:
CancerChronic Health Problems in Survivors of Adolescent and Young Adult Cancer
The goal of this project is to evaluate the long-term health outcomes, including mortality, second cancer and comorbidities among survivors of adolescent and young adult cancer. The magnitude of risk increase of specific late effects associated with specific cancer therapeutic exposure will also be characterized.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
American Cancer SocietyFunding Years:
2015 - 2019Chronic Myelogenous Leukemia and Outcomes of Tyrosine Kinase Inhibitor Therapy
The aim of this investigation initiated retrospective cohort study are to examine long-term health effects in the cohort of CML and determine if health effects vary by drug adherence to TKIs.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
Novartis Pharmaceuticals CorporationFunding Years:
2013 - 2018Comparing Strategies for Implementing Primary HPV Testing for Routine Cervical Cancer Screening
The major goal of this project is to compare two implementation strategies to facilitate adoption of primary HPV testing for routine cervical cancer screening measured by patient-, provider- and system-centered outcomes. A sub-analysis and survey data collection will evaluate the impact of the COVID pandemic on this practice change and cervical cancer screening.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
Patient-Centered Outcomes Research Institute (PCORI)Funding Years:
2019 - 2023Research Categories:
Cancer, Comparative Effectiveness, COVID-19, Patient-Reported Outcomes, Women's HealthDeveloping tailored de-implementation strategies to reduce use of low-value cancer care services
The goal of this mixed methods study is to develop and test interventions to reduce use of surveillance biomarkers for early stage breast cancer patients.
Principal Investigator:
Erin E. Hahn, PhD, MPHFunding Source:
Kaiser Permanente, Southern CaliforniaFunding Years:
2014 - 2015Diet and Lifestyle in a Prospective Study of Bladder Cancer Survivors
This study will examine the role of cruciferous vegetable intake, in conjunction with genetic polymorphisms related to ITC metabolism, in potentially reducing disease recurrence and progression, and increasing the efficacy of intravesical bladder cancer treatment.
Economic, Epidemiologic and Clinical Burden Associated with Neutropenia and Febrile Neutropenia in Three Cancers
The primary objective of this study is to estimate the resource utilization and direct medical expenditure associated with neutropenia and febrile neutropenia, in Non-Hodgkin’s Lymphoma, Breast cancer and Lung cancer patients. The secondary objective is to determine the trend of incidence of neutropenia with and without fever in Non-Hodgkin’s Lymphoma, Breast cancer and Lung cancer. The study will also describe management patterns and evaluate trend of management patterns for febrile neutropenia. Lastly, we will also estimate the febrile neutropenia specific mortality rate in hospitalized patients by cancer type.
Principal Investigator:
Aniket A. Kawatkar, PhD, MSFunding Source:
Amgen, Inc.Funding Years:
2011 - 2015End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures.
Adolescents and young adults with cancer aged 12-39 account for more than 70,000 new cancer diagnoses in the United States per year, and cancer is their leading disease-related cause of death. This study will evaluate the current state of end-of-life care quality among adolescent and young adult patients and develop a set of quality indicators that capture adolescent and young adult values for care. This work will enable valid assessment of care quality and rigorous evaluation of interventions to improve adolescent and young adult end-of-life care delivery.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
National Cancer Institute (NCI)Funding Years:
2018 - 2023Follow-up care and preventive service use among survivors of adolescent and young adult cancer.
This project aims to evaluate adherence to Children’s Oncology Group Long-Term Follow-up Guidelines and population preventive care guidelines among survivors of adolescent and young adult (AYA) cancer.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
Not ApplicableFunding Years:
2016Hereditary Cancer Moderate Risk Gene Results vs. Claus Model Breast Cancer Risk Score and Breast MRI
Dr. Haque was awarded travel funds to attend conferences related to hereditary cancers.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
GeneDxFunding Years:
2015 - 2018Research Categories:
CancerIdentification of DNA methylation markers for risk of metastasis in localized prostate
The goal of this project is to develop DNA methylation marker-based prediction algorithms that will assist clinicians when providing therapeutic recommendations for men with localized prostate cancer.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
National Institutes of Health (NIH)Funding Years:
2015 - 2021Impact of Bariatric Surgery on Cancer Incidence in Severely Obese Adults
The goal of this project is to estimate the impact of bariatric surgery versus routine non-surgical care on the incidence of cancer (all types) in all severely obese patients (men and women).
Principal Investigator:
Corinna Koebnick, PhD, MScFunding Source:
National Cancer Institute (NCI)Funding Years:
2014 - 2018Implementing systematic distress screening in breast cancer
This project focuses on implementation and effectiveness of an evidence-based guideline recommendation for systematic distress screening for breast cancer patients.
Principal Investigator:
Erin E. Hahn, PhD, MPHFunding Source:
Not ApplicableFunding Years:
2016Kaiser Permanente NCI National Community Oncology Research Program-Cancer Care Delivery Research Program
The specific aim of the Cancer Care Delivery Research portion of this program is to conduct and help design cancer care delivery research within the National Community Oncology Research Program (NCORP
Molecular and Genetic Determinants of non-Hodgkin Lymphoma
The goal of this study is to investigate whether the genetic variation in the human leukocyte antigen and other key a priori genes linked to human leukocyte antigen, including tumor necrosis factor play a role in non-Hodgkin lymphoma prognosis and overall survival.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
National Cancer Institute (NCI)Funding Years:
2012 - 2017Next Generation Sequencing Testing to Inform Clinical Decision-Making for Non-Small Cell Lung Cancer (NSCLC) in a Large Integrated Healthcare Delivery System
The goal of this study is to examine the effectiveness of NGS testing (tissue failure rates, time to NGS results), distribution of NGS testing, and prevalence of targetable driver mutations by patient’s demographic and clinical characteristics.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
Care Improvement ResearchFunding Years:
2022Research Categories:
CancerObservational Study of the Epidemiology in Clinical Outcomes of Breast Cancer in Women with BRCA Mutations
This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
AstraZenecaFunding Years:
2015 - 2019OPATS: Outcomes of Prostate Cancer Androgen Deprivation Therapy Study
The goal is to assess fatal and morbid outcomes up to 15 years following androgen deprivation therapy for men initially diagnosed with localized prostate cancer.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2010 - 2014PD-1/PD-L1 Blockage Plus Kinase Inhibitor Therapies for B cell Lymphomas
This study aims to explore rational combination therapies aimed at cytoreduction of advanced tumors followed by antibody-mediated immune checkpoint inhibition to stimulate adaptive T cell anti-lymphoma immunity. We will study a large cohort of human diffuse large B cell (DLBCL) samples and utilize syngeneic, immunocompetent mouse lymphoma models that mimic the varied sensitivity of human B cell NHL to kinase inhibitors
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
Leukemia and Lymphoma SocietyFunding Years:
2013 - 2016Personalized Risk-Adaptive surveIllance Strategies in cancEr (PRAISE)
The major goals of this project are to develop innovative risk-adaptive models of cancer surveillance for colorectal, chronic myeloid leukemia, and prostate cancer using value-of-information statistical methodology.
Site Principal Investigator:
Erin E. Hahn, PhD, MPHFunding Source:
Nat'l Inst of HealthFunding Years:
2018Research Categories:
CancerPilot Study of Neutropenia in Cancer Patients with Co-Morbid Conditions
The goal of this study is to evaluate the feasibility of determining the occurrence of neutropenia and febrile neutropenia as well as cancer treatment using electronic medical records.
Principal Investigator:
Chun Chao, PhD, MSFunding Source:
Amgen, Inc.Funding Years:
2009Research Categories:
CancerREPRISE 2: Is depression associated with prostate cancer progression?
This study examines if depression and its treatment can affect the course of prostate cancer.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2018 - 2022Risk Factors for molecular subtypes of NHL- a prospective evaluation
This study aims to evaluate purported risk factors for NHL and its subtypes using a pooled analysis of>500,000 individuals from five cohort studies
Site Principal Investigator:
Chun Chao, PhD, MSFunding Source:
National Cancer Institute (NCI)Funding Years:
2016 - 2021Research Categories:
CancerRisk of Cancer in Childhood and Adolescence Associated with Medical Imaging
The goal of this study it to evaluate patterns of medical imaging associated with cumulative exposure to radiation (CT, nuclear medicine, fluoroscopy, angiography, and radiography), and subsequent risk of childhood cancers.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2015 - 2020Research Categories:
Cancer, Child and Adolescent Health, Health Services Research, Maternal and Child HealthRisk prediction of breast cancer treatment-related cardiotoxicity to guide clinical decision making
The aim of this cohort study is to examine how combined breast cancer adjuvant therapies affect the risk of developing early and late cardiovascular disease. Results will be used to develop risk prediction models to inform clinical decision-making to optimize cancer control while mitigating cardiovascular disease risk.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Heart, Lung, and Blood Institute (NHLBI)Funding Years:
2020 - 2024Sleep Disturbance, Inflammation & Cellular Aging in Breast Cancer Survivors (STRIVE 2)
The goal of this prospective recruitment study is to evaluate longitudinal differences in the rates of change in inflammation and telomere erosion in breast cancer survivors vs. non-cancer comparison women to determine if such molecular changes are due to cancer biology, or its treatment, or consequences of aging.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2016 - 2022Sleep Inflammation and Depression Occurrence in Breast Cancer Survivors (STRIVE1)
The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2012 - 2019Use of Multiple Biomarkers with the Risk of Ovarian Cancer Algorithm (ROCA) for Early Detection of Ovarian Cancer in Female Carriers of BRCA1 and BRCA2 mutations
The goal of this prospective recruitment study is to determine if ovarian cancer screening is enhanced by more frequent biomarker testing (CA125 & HE4) versus usual testing frequency in women with BRCA1/2 mutations.
Principal Investigator:
Reina Haque, PhD, MPHFunding Source:
Garfield Memorial FundFunding Years:
2016 - 2019Using Stakeholder Perspectives to Improve Survivorship Care Plan Implementation
The goal of this study is to gain insight and understanding into planned and implemented processes of survivorship care in diverse health care settings.
Principal Investigator:
Erin E. Hahn, PhD, MPHFunding Source:
National Cancer Institute (NCI)Funding Years:
2016 - 2017Utilization and Impact of Extended-Interval Dosing of Immunotherapy on Outcomes in Patients with Locally Advanced NSCLC
A retrospective analysis to evaluate the utilization of Q2W and dosing of durvalumab and impact on treatment outcomes among patients with unresectable stage III NSCLC treated within the Kaiser Permanente integrated delivery system.