Women's Health studies

We examine a broad range of health issues affecting women, covering preventive care, disease screening and treatment, pregnancy and childbirth, health equity, and service delivery. Current studies focus on osteoporosis, breast cancer survivorship, and the relationship between pregnancy and other health issues such as multiple sclerosis.

Adverse Health Outcomes in Breast Cancer Survivors exposed to Pain Medications

The aim of this longitudinal cohort study is to evaluate the comparative safety and risk of opioids and psychotropic drugs in women with breast cancer who suffer from chronic pain due to cancer or its treatments.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

California Breast Cancer Research Program (CBCRP)

Funding Years:

2020 - 2023

Air Pollution and Pregnancy Complications in Complex Urban Environments: Risks, Heterogeneity, and Mechanisms (APPCUE)

To advance the understanding of the impact of air pollutant mixture and the built environment on pregnancy complications (gestational diabetes, gestational hypertension, and pre-eclampsia/eclampsia) and outcomes by leveraging prospectively- recorded and high-quality maternal clinical data from the electronic health record and address data with state-of-the-art spatiotemporal air pollution modeling and novel statistical methods that examine both individual and composite exposure profiles.

Principal Investigator:

Darios Getahun, MD, PhD, MPH

Funding Source:

National Institute of Environmental Health Sciences (NIEHS)

Funding Years:

2019 - 2023

An Intervention Study of Reminder Letter for Gardasil Regimen Completion

The goal of this randomized intervention study is to evaluate the effectiveness of a quarterly mailing intervention on human papillomavirus vaccine three-dose regimen completion.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Merck & Co., Inc.

Funding Years:

2012 - 2016

Antidepressants and Breast Cancer Pharmacoepidemiology

This study examines drug interactions between tamoxifen and antidepressants in nearly 23,000 breast cancer survivors diagnosed with early stage disease in the two largest health plans in California.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2010 - 2014

Research Categories:

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Comparing Strategies for Implementing Primary HPV Testing for Routine Cervical Cancer Screening

The major goal of this project is to compare two implementation strategies to facilitate adoption of primary HPV testing for routine cervical cancer screening measured by patient-, provider- and system-centered outcomes. A sub-analysis and survey data collection will evaluate the impact of the COVID pandemic on this practice change and cervical cancer screening.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Patient-Centered Outcomes Research Institute (PCORI)

Funding Years:

2019 - 2023

Digital Mindfulness Based Cognitive Therapy for Perinatal Depression

Mindfulness Based Cognitive Therapy (MBCT) an 8-session in-person intervention using mindfulness meditation and cognitive-behavioral strategies, has shown effectiveness in reducing residual depressive symptoms and risk for recurrence among pregnant women with histories of depression. A digital adaptation of MBCT for pregnant women, Mindful Mood Balance for Moms (MMBFM), was recently developed to overcome access barriers to in-person groups and increase potential for scale-up in OB care settings. We will address the following aims for this study: 1) Compare the clinical effectiveness (i.e. engagement and symptom reduction) of MMBFM supported by clinician vs. peer coaches among women with a history of prior depressive episodes; 2) examine specific mechanisms of action for MMBFM participants receiving clinician vs. peer coaching; 3) examine the effects of specific implementation strategies on reach of the MMBFM program; and 4) estimate the cost-effectiveness of MMBFM supported by clinician vs. peer coaches. We hypothesize that MMBFM will be more cost-effective when supported by peer vs. clinician coaches.

Site Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

National Institute of Mental Health (NIMH)

Funding Years:

2019 - 2024

Impact of Bariatric Surgery on Cancer Incidence in Severely Obese Adults

The goal of this project is to estimate the impact of bariatric surgery versus routine non-surgical care on the incidence of cancer (all types) in all severely obese patients (men and women).

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2014 - 2018

Research Categories:

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Incidence and trend of ectopic pregnancy 2008-2017: a population-based study

Examining the recent trends in ectopic pregnancy among women of childbearing ages.

Principal Investigator:

Darios Getahun, MD, PhD, MPH

Funding Source:

Bayer Pharmaceuticals Corporation

Funding Years:

2018 - 2019

Research Categories:

Moderate Hypertension in Pregnancy: Safety and Effectiveness of Treatment

Evaluating the effect of treating mild-to-moderate hypertension in pregnancy, compare the risks of clinically important outcomes with different medications, and determine whether the benefits and risks vary by maternal race/ethnicity or obesity status.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Institute of Child Health and Human Development (NICHD)

Funding Years:

2015 - 2020

Sleep Inflammation and Depression Occurrence in Breast Cancer Survivors (STRIVE1)

The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2012 - 2019

The Bariatric Experience Long Term (BELONG) II for Racial and Ethnic Minority Patients

Effective treatments for severe obesity are particularly needed in racial/ethnic minority populations. Rates of severe obesity are as high as 36% for middle-aged non-Hispanic black women compared to 16% for their white counterparts in the U.S. Research on bariatric weight loss outcomes among racial/ethnic minorities is limited. What evidence does exist suggests that black patients consistently lose less weight than whites over 2–3 years of follow-up. The evidence for differences between Hispanic and white or black bariatric patients is equivocal. Hispanic patients have been shown to lose more, less, or the same amount of weight as non-Hispanic black and white patients. Across studies, the disparities in % total weight loss vary from less than 2% to 10%. This variability is twice as much as the amount of weight loss considered clinically meaningful. This study will extend the work done by our team during the Bariatric Experience Long-Term (BELONG) study which addressed how self-reported behavioral, psychosocial, and perceived environmental factors predicted weight loss over 3 years following gastric bypass and sleeve. Patients (n = 1,975) were 41% Hispanic, 17% non-Hispanic black, and 37% non-Hispanic white. The proposed study will expand the work of BELONG by incorporating: 1) A focus on weight regain during 3-5 years after surgery; 2) measures shown to contribute to health disparities in severe obesity (vigilant coping style and internalized racism); and 3) innovative qualitative methods (photo-elicitation and ethnography) to understand the patient experience.

Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

National Center on Minority Health & Health Disparities (NIMHD)

Funding Years:

2019 - 2023

Use of Multiple Biomarkers with the Risk of Ovarian Cancer Algorithm (ROCA) for Early Detection of Ovarian Cancer in Female Carriers of BRCA1 and BRCA2 mutations

The goal of this prospective recruitment study is to determine if ovarian cancer screening is enhanced by more frequent biomarker testing (CA125 & HE4) versus usual testing frequency in women with BRCA1/2 mutations.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

Garfield Memorial Fund

Funding Years:

2016 - 2019