Molecular Epidemiology studies
Chronic Myelogenous Leukemia and Outcomes of Tyrosine Kinase Inhibitor Therapy
The aim of this investigation initiated retrospective cohort study are to examine long-term health effects in the cohort of CML and determine if health effects vary by drug adherence to TKIs.
GWU/Wellcome 1 Feasibility
To collect preliminary data to support the larger Wellcome grant.
Learning from California Senate bill 27: a natural experiment
This study complements an ongoing R01 study to provide more compelling evidence regarding the impact of SB27 by examining all major meat types (chicken, turkey, pork and beef) that may be impacted by the bill. Likewise, we include collection of the frank foodborne pathogens, Salmonella and Campylobacter, to provide additional insights into the potential effectiveness of this policy intervention.
Molecular and Genetic Determinants of non-Hodgkin Lymphoma
The goal of this study is to investigate whether the genetic variation in the human leukocyte antigen and other key a priori genes linked to human leukocyte antigen, including tumor necrosis factor play a role in non-Hodgkin lymphoma prognosis and overall survival.
Observational Study of the Epidemiology in Clinical Outcomes of Breast Cancer in Women with BRCA Mutations
This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.
PD-1/PD-L1 Blockage Plus Kinase Inhibitor Therapies for B cell Lymphomas
This study aims to explore rational combination therapies aimed at cytoreduction of advanced tumors followed by antibody-mediated immune checkpoint inhibition to stimulate adaptive T cell anti-lymphoma immunity. We will study a large cohort of human diffuse large B cell (DLBCL) samples and utilize syngeneic, immunocompetent mouse lymphoma models that mimic the varied sensitivity of human B cell NHL to kinase inhibitors
Transcriptomic Classification of Non-muscle Invasive Bladder Cancer and its Clinical and Prognostic Implication
The goal of this project is to define molecular subtypes of non-muscle invasive bladder cancer using data and samples from the Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be-Well), the largest prospective cohorts of newly diagnosed bladder cancer patients, with an ultimate goal to identify molecular signatures to refine the current pathological risk stratification and inform treatment response prediction.