Child and Adolescent Health studies

Child and adolescent health includes a wide range of chronic and acute physical and mental health conditions. Our research focuses on the prevention, screening, and treatment of disease. We also examine quality of life and quality of care among children and adolescents with conditions such as diabetes, asthma, cancer, and obesity, as well as behavioral, developmental, and mental health conditions.

A Sequential Multiple Assignment Randomized Trial (SMART) Assessing Medication and CBT Sequencing Strategies in the Treatment of Predominantly Ethnic Minority, Underserved Youth with Anxiety Disorders

Anxiety disorders affect more than 20 percent of youth, often interfering with self-esteem, confidence, family relationships, friendships, or school performance. Although psychological and medication therapies are helpful to many patients, not all patients respond to a given therapy, and those who do frequently respond relapse later. Treatment of a child who has an anxiety disorder begins with the question of which treatment to begin first: psychological or medication therapy. Few studies, however, have compared these two treatments directly, leaving patients, parents, and clinicians without scientific evidence for which treatment is likely to be most helpful. Another question is what to do when the initial treatment is not as helpful as desired: Should the initial single treatment be intensified, or should the other treatment be added to the first, producing a combined psychological and medication therapy? This randomized trial will clarify whether treatment of anxiety should be initiated with medication or cognitive-behavioral therapy and how to proceed if the initial treatment is not as successful as desired.

Site Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

Patient-Centered Outcomes Research Institute (PCORI)

Funding Years:

2021 - 2024

Chronic Health Problems in Survivors of Adolescent and Young Adult Cancer

The goal of this project is to evaluate the long-term health outcomes, including mortality, second cancer and comorbidities among survivors of adolescent and young adult cancer. The magnitude of risk increase of specific late effects associated with specific cancer therapeutic exposure will also be characterized.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

American Cancer Society

Funding Years:

2015 - 2019

Research Categories:

,

Effects of air pollution and gestational diabetes on autism

The proposal will gather preliminary biomarker data in newborns in response to air pollution and gestational diabetes exposure in-utero

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

Not Applicable

Funding Years:

2017

End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures.

Adolescents and young adults with cancer aged 12-39 account for more than 70,000 new cancer diagnoses in the United States per year, and cancer is their leading disease-related cause of death. This study will evaluate the current state of end-of-life care quality among adolescent and young adult patients and develop a set of quality indicators that capture adolescent and young adult values for care. This work will enable valid assessment of care quality and rigorous evaluation of interventions to improve adolescent and young adult end-of-life care delivery.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2018 - 2023

Research Categories:

,

Follow-up care and preventive service use among survivors of adolescent and young adult cancer.

This project aims to evaluate adherence to Children’s Oncology Group Long-Term Follow-up Guidelines and population preventive care guidelines among survivors of adolescent and young adult (AYA) cancer.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Not Applicable

Funding Years:

2016

Research Categories:

,

Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2015 - 2021

Post-licensure observational safety surveillance study of quadrivalent meningococcal ACWY conjugate vaccine in children 2-23 months of age

This study is an observational post-marketing safety study required by the United States Food and Drug Administration (FDA). The primary objective of this study is to describe medical events that require emergency room visit or hospitalization in 6 months following MenACWY-CRM vaccination in children 2-23 months of age in a health maintenance organization (HMO) in the United States.

Principal Investigator:

Hung Fu Tseng, PhD, MPH

Funding Source:

Novartis Vaccines and Diagnostics, Inc.

Funding Years:

2014 - 2018

Reducing Childhood Obesity through EHR-supported Motivational Interviewing

Rates of childhood obesity in the U.S. remain at historic highs. Primary care settings lack interventions to address the childhood obesity epidemic that are feasible and sustainable without requiring significant resources. We will test a motivational interviewing-based intervention shown to lower children’s BMI in a real-world clinical setting with the goal of halting and reversing the childhood obesity epidemic.

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2021 - 2026

Risk of Cancer in Childhood and Adolescence Associated with Medical Imaging

The goal of this study it to evaluate patterns of medical imaging associated with cumulative exposure to radiation (CT, nuclear medicine, fluoroscopy, angiography, and radiography), and subsequent risk of childhood cancers.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2015 - 2020

SEARCH for Diabetes in Youth Cohort (Follow-Up) Study

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2015 - 2020

The association between Cesarean Delivery, Labor and Body Weight in Children.

This project is part of a series of CDC studies to better understand the association between birth factors such as delivery mode labor or rupture of membrane, and exposure to intrapartum antibiotics and childhood weight gain.

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2019 - 2020

Trajectories of Physical Activity and Sedentary Time in Adolescent/Young Women (TAAG 3)

The major goals of this trial are to determine the effectiveness of a school and community-linked physical activity intervention to reduce the decline in physical activity in young women, a cohort who have been followed since middle school.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

Kaiser Permanente and Johns Hopkins Medicine Research Collaboration Committee

Funding Years:

2017 - 2018

Using Computational Approaches to Optimize Asthma Care Management

This project aims to improve the accuracy of computationally identifying high-risk asthma patients, it’s assess potential impact on outcomes and to provide automated prediction result explanations for care management.

Site Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

National Heart, Lung, and Blood Institute (NHLBI)

Funding Years:

2018 - 2022