Child and Adolescent Health studies
Chronic Health Problems in Survivors of Adolescent and Young Adult Cancer
The goal of this project is to evaluate the long-term health outcomes, including mortality, second cancer and comorbidities among survivors of adolescent and young adult cancer. The magnitude of risk increase of specific late effects associated with specific cancer therapeutic exposure will also be characterized.
Effects of air pollution and gestational diabetes on autism
The proposal will gather preliminary biomarker data in newborns in response to air pollution and gestational diabetes exposure in-utero
End-of-Life Care for Adolescents and Young Adults with Cancer: An Evaluation of Care and Development of Patient-Centered Quality Measures.
Adolescents and young adults with cancer aged 12-39 account for more than 70,000 new cancer diagnoses in the United States per year, and cancer is their leading disease-related cause of death. This study will evaluate the current state of end-of-life care quality among adolescent and young adult patients and develop a set of quality indicators that capture adolescent and young adult values for care. This work will enable valid assessment of care quality and rigorous evaluation of interventions to improve adolescent and young adult end-of-life care delivery.
Follow-up care and preventive service use among survivors of adolescent and young adult cancer.
This project aims to evaluate adherence to Children’s Oncology Group Long-Term Follow-up Guidelines and population preventive care guidelines among survivors of adolescent and young adult (AYA) cancer.
Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site
The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)
Post-licensure observational safety surveillance study of quadrivalent meningococcal ACWY conjugate vaccine
This study is an observational post-marketing safety study required by the United States Food and Drug Administration (FDA). The primary objective of this study is to describe medical events that require emergency room visit or hospitalization in 6 months following MenACWY-CRM vaccination in children 2-23 months of age in a health maintenance organization (HMO) in the United States.
Risk of Cancer in Childhood and Adolescence Associated with Medical Imaging
The goal of this study it to evaluate patterns of medical imaging associated with cumulative exposure to radiation (CT, nuclear medicine, fluoroscopy, angiography, and radiography), and subsequent risk of childhood cancers.
SEARCH for Diabetes in Youth Cohort (Follow-Up) Study
The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study
The HAPO Follow-up Study will recruit from the cohort of women and their offspring who participated in the original HAPO Study to test the hypothesis that hyperglycemia in pregnancy, less severe than overt diabetes, is independently associated with increased risk of adverse childhood and maternal outcomes 8-12 years later. The general aim of the study is to obtain measures of adiposity, glucose, insulin sensitivity and secretion, lipids, inflammation and blood pressure in 7,000 HAPO mother-offspring (aged 8-12) pairs of multiple ethnic/race groups from ten of the original HAPO field centers. (RO1DK061628)
Site Principal Investigator:Jean M. Lawrence, ScD, MPH, MSSA
Funding Source:National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Funding Years:2012 - 2017
Trajectories of Physical Activity and Sedentary Time in Adolescent/Young Women (TAAG 3)
The major goals of this trial are to determine the effectiveness of a school and community-linked physical activity intervention to reduce the decline in physical activity in young women, a cohort who have been followed since middle school.
Using Computational Approaches to Optimize Asthma Care Management
This project aims to improve the accuracy of computationally identifying high-risk asthma patients, it’s assess potential impact on outcomes and to provide automated prediction result explanations for care management.