Approaches to Genetic Heterogeneity of Obstructive Sleep Apnea
The main goal of this study is to use state of the art approaches to identify relevant genes based on a very large sample of patients with Obstructive Sleep Apnea (OSA), a common disorder with multiple adverse consequences. It is known that OSA has a genetic basis, but to date no convincing gene variants have been identified. This study uses OSA obtained from multiple institutions in the United States. It is the largest study ever proposed for identifying genes for this common sleep disorder.
Genetics of Beta Cell Failure in Mexican Americans: Phase II (Beta Gene II)
This application is proposed to call back ~400 individuals in our previous cross-sectional BetaGene cohort study (NIDDK 61628) and re-test them for phenotypes. Analysis will be conducted to determine which genes and how they interact with each other to impact the longitudinal changes in beta-cell function and other T2DM related traits.
Observational Study of the Epidemiology in Clinical Outcomes of Breast Cancer in Women with BRCA Mutations
This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.
Physiologic Consequence of Genetic Variation (BetaGene III)
The over-arching goal of this study is to assess the physiologic effect of genetic variation in humans and determine how variation in genes alters physiologic processes to contribute to diabetes pathogenesis.