About Our Program

As a research center embedded within Kaiser Permanente’s large and dynamic health care system, our investigators have a unique opportunity to apply scientific expertise to real-world clinical problems, translate findings into practice, and share what we learn with the broader community.

Featured Scientist

Dr. Gary Buchschacher
Gary L. Buchschacher Jr., MD, PhD
Principal Investigator
Los Angeles Medical Center


Dr. Gary Buchschacher is the director of the Cancer Clinical Trials Access Program. He coordinates and leads the program’s activities and acts as principal investigator for numerous studies. He is the site PI for the Kaiser Permanente Los Angeles Medical Center and a member of its Oncology Steering Committee.

Dr. Buchschacher is the medical oncology lead for the Southern California Permanente Medical Group’s Gastrointestinal Cancer Subcommittee and a member of the Regional Cancer ...

Featured Video

Advancing treatments through clinical trials

Over the years, clinical trials have led to amazing advances in treatment—even cures—for devastating illnesses. William Towner, MD, FACP, FIDSA, regional physician director for clinical trials, describes how trials at Kaiser Permanente contribute to the development of more effective and safer treatments for diseases such as HIV, hepatitis C, cancer, and more. (2:15)


Featured Image of News Story Titled: Paxlovid associated with lower risk of hospital admission

Paxlovid associated with lower risk of hospital admission

A Kaiser Permanente study confirms the benefit of nirmatrelvir-ritonavir, also known as Paxlovid, as an early-stage treatment to prevent hospitalization for people with mild to moderate COVID-19, regardless of prior immunity or age. The study was published March 15, 2023, in The Lancet Infectious Diseases. “Among Kaiser Permanente members in Southern California who tested positive ...

Extra pounds put kids at higher risk for hypertension

A study of more than 800,000 young people between the ages of 3 and 17 showed that youth at the upper range of average  weight had a 26% higher risk of developing hypertension than those closer to what is considered average weight. The study was published March 14, 2023, in JAMA Network Open. “Hypertension during ...

Kaiser Permanente Southern California selected for initiative aimed at improving patient outcomes

The Patient-Centered Outcomes Research Institute (PCORI) has selected Kaiser Permanente Southern California as one of 42 health systems nationwide to carry out a pioneering initiative aimed at improving patient outcomes. As a participant in PCORI’s Health Systems Implementation Initiative (HSII), Kaiser Permanente Southern California will bring its on-the-ground experience and expertise in health care innovation ...

Dr. William Towner named 2022 SCPMG Physician Researcher of the Year

William J. Towner, MD, FACP, FIDSA, physician director of the Kaiser Permanente Southern California Clinical Trials Program, has been named the 2022 Southern California Permanente Medical Group Physician Researcher of the Year. The award has been given each year since 2007 to recognize a physician or surgeon for his or her outstanding contributions to the research ...

Original COVID-19 vaccine booster effect wanes against BA.4 and BA.5

A Kaiser Permanente study published January 12, 2023, in Nature Communications shows that third and fourth doses of the monovalent Moderna mRNA-1273 COVID-19 vaccine lose protection against infection with omicron subvariants after 3 months, but protection against hospitalization remains high in adults 18 years of age or older. “This study provides important data on the ...


Featured Division

Health Services Research & Implementation Science

Our health services researchers bring together scientific and clinical expertise to find better ways to improve care.

Investigators with the Division of Health Services Research & Implementation Science study how care is delivered, identify opportunities for care improvement, and implement new approaches for organizing and delivering health services. The division brings together scientists with diverse expertise and training, including emergency medicine, epidemiology, health services research, implementation science, internal medicine, nursing, pharmaceutical economics, and pulmonology.

The division is home to the Care Improvement Research Team, a research team embedded within Kaiser Permanente Southern California’s quality improvement ecosystem. The team works closely with clinical and operational partners at Kaiser Permanente Southern California to identify, prioritize, and solve problems related to quality and affordability. Its goal is to reduce unnecessary practice variation, improve affordability, and transform care.