Mental Health studies

Our investigators research the role of mental illness in the development of chronic diseases, especially cardiovascular disease, obesity, and cancer. We also study mental health in children and adolescents, smoking and depression in teens, and psychosocial distress and treatment among breast cancer survivors. We participate in the HMO Mental Health Research Network, which is building the infrastructure for large multi-center research studies on the causes and treatment of mental illness in managed care settings.

Biobehavioral Vulnerability to Accelerated Aging in Breast Cancer Survivors

The aim of this project is to examine cellular and genomic markers of inflammation, telomere erosion, telomere length, and microarray data of 300 breast cancer survivors and comparison women who are enrolled in the KPSC-UCLA collaborative STRIVE1 and STRIVE2 studies.

Site Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

American Cancer Society

Funding Years:

2016 - 2019

Depression and Functional Outcomes in COPD: Impact of Genetics and Inflammation

This is a longitudinal observational study of the biological causes and functional consequences of depression in patients with stable COPD.

Principal Investigator:

Huong Q. Nguyen, PhD, RN

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2013 - 2016

Research Categories:

Development of a Population-Based Risk Calculator for Suicidal Behavior

We will use population-based data from seven large health systems to develop an evidence-based risk calculator for mental health and primary care clinicians. In order to address the gaps in evidence described above, we will expand current MHRN work on prediction of suicide risk by (1) expansion to a larger and more diverse sample, (2) Inclusion of encounters with “missing” risk assessments, (3) Examination of specific psychiatric and substance use diagnoses, and (4) applying analytic methods to account for potential biases due to patient- and provider-driven timing of assessments.

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Mental Health (NIMH)

Funding Years:

2015 - 2017

Research Categories:

Patterns and Predictors of Transitions in Adult Attention-Deficit Hyperactivity Disorder

This study will estimate the epidemiologic and economic outcomes associated with the adult attention deficit hyperactivity disorder (ADHD). We also assess characteristics, predictors, and time frame for patients who transition to more complex ADHD within the inception cohort and generate prediction models for transition. The study also examines treatment patterns, medication adherence and healthcare utilization patterns of the inception cohort.

Principal Investigator:

Aniket A. Kawatkar, PhD, MS

Funding Source:

Shire Pharmaceuticals

Funding Years:

2009 - 2012

REPRISE 2: Is depression associated with prostate cancer progression?

This study examines if depression and its treatment can affect the course of prostate cancer.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2018 - 2020

Research Categories:

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Sleep Disturbance, Inflammation & Cellular Aging in Breast Cancer Survivors (STRIVE 2)

The goal of this prospective recruitment study is to evaluate longitudinal differences in the rates of change in inflammation and telomere erosion in breast cancer survivors vs. non-cancer comparison women to determine if such molecular changes are due to cancer biology, or its treatment, or consequences of aging.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2016 - 2019

Sleep Inflammation and Depression Occurrence in Breast Cancer Survivors (STRIVE1)

The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.

Site Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2012 - 2017