Diabetes studies

The incidence of type 2 diabetes is increasing globally as the prevalence of obesity increases, and the incidence of type 1 diabetes is also on the rise. Patients are being diagnosed with both types of diabetes at younger ages. Our researchers study the genetics, prevention, treatment, quality of care, and health outcomes of patients with diabetes.

Beta Cell Restoration through Fat Migation

The major goal of this project is to develop approaches that can arrest or reverse progressive Beta-cell disease.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

Nat'l Inst of Diab & Digestive & Kidney

Funding Years:

2011

Research Categories:

CV Benefits and Safety of Glucose-Lowering Therapies in Adults with Diabetes

The primary goal of this study is to assess the impact of specific glucose-lowering strategies on cardiovascular events and on mortality in order to identify whether some glucose-lowering strategies confer more cardiovascular benefit than others.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Heart, Lung, and Blood Institute (NHLBI)

Funding Years:

2014 - 2018

Research Categories:

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Genetics of Beta Cell Failure in Mexican Americans: Phase II (Beta Gene II)

This application is proposed to call back ~400 individuals in our previous cross-sectional BetaGene cohort study (NIDDK 61628) and re-test them for phenotypes. Analysis will be conducted to determine which genes and how they interact with each other to impact the longitudinal changes in beta-cell function and other T2DM related traits.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2009 - 2014

Research Categories:

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Incidence of Type 1 Diabetes in a Racially and Ethnically Diverse Cohort of Young Adults 20-45 Years of Age

Diabetes in Young Adults (DiYA) Study: While there has been significant progress in the past 15 years in understanding the incidence and prevalence of type 1 diabetes (T1D) in U.S. children, corresponding data on new-onset type 1 diabetes in adults 20-45 years is very limited. Our study will provide this vital information and guide efforts to expand surveillance of type 1 diabetes in young adults. Aim 1: Develop and implement rapid and complete case ascertainment of incident diabetes cases among young adults aged 20-45 years. Aim 2: Draw blood within 6 months of diabetes diagnosis for measurements of DAA. Aim 3: Establish a population-based registry of incident diabetes cases among adults 20-45 years of age. Aim 4: Estimate the incidence of T1D in this age group by sex and race/ethnicity. Aim 5: provide a novel framework to evaluate a diabetes surveillance system in terms of accuracy, timeliness and costs. 1 U18 DP006289-01

Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2016

Research Categories:

Physiologic Consequence of Genetic Variation (BetaGene III)

The over-arching goal of this study is to assess the physiologic effect of genetic variation in humans and determine how variation in genes alters physiologic processes to contribute to diabetes pathogenesis.

Site Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

Nat'l Inst of Diab & Digestive & Kidney

Funding Years:

2015

Research Categories:

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Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2015 - 2021

Randomized Trial of Exercise Promotion In Primary Care (EPPC)

To determine the feasibility of a primary care based, telephone counseling physical activity behavioral intervention for diabetics and prediabetics.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2014 - 2016

Randomized Trial of Exercise Promotion in Primary Care (EPPC)

EPPC is testing the effects of a 2-year motivational interview, telephone-based intervention on increasing moderate to vigorous physical activity among participants with diabetes and prediabetes.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2019 - 2024

Risk Trajectory of Comorbidities Across Natural History of Diabetes

The goal of this study is to examine the long-term development of complications over the course of type 2 diabetes and estimate the incidence of complications including cardiovascular disease, chronic kidney disease, end-stage renal disease, neuropathy, diabetic retinopathy to inform strategies to reduce the burden of type 2 diabetes complications.

Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2018 - 2020

SEARCH for Diabetes in Youth Cohort (Follow-Up) Study

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2015 - 2020

SEARCH Nutrition Ancillary Study 2 (SNAS2)

The goal of SNAS2 is to examine associations of nutritional factors with 1) markers of subclinical cardiovascular disease; 2) prevalence and severity of retinopathy; and 3) prevalence, severity and incidence of diabetic kidney disease in youth with type 1 diabetes and type 2 diabetes. (2R01DK077949)

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2014 - 2018

Research Categories:

The Economic Benefits of Triglyceride Lowering Among Patients with Diabetes and Severe Hypertriglyceridemia

The overall goal of this non-interventional study is to analyze the economic impact of triglyceride lowering and to determine whether this differs among patients who did and did not receive therapy to intentionally lower triglycerides.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

AstraZeneca

Funding Years:

2015 - 2016

Research Categories:

,

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study

The HAPO Follow-up Study will recruit from the cohort of women and their offspring who participated in the original HAPO Study to test the hypothesis that hyperglycemia in pregnancy, less severe than overt diabetes, is independently associated with increased risk of adverse childhood and maternal outcomes 8-12 years later. The general aim of the study is to obtain measures of adiposity, glucose, insulin sensitivity and secretion, lipids, inflammation and blood pressure in 7,000 HAPO mother-offspring (aged 8-12) pairs of multiple ethnic/race groups from ten of the original HAPO field centers. (RO1DK061628)

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2012 - 2017

The Role of Adipokines in Glucose Regulation and Metabolic Decline

This project measured a large panel of pro- and anti-inflammatory adipokines in existing blood samples collected from BetaGene I and II study participants, combine these data with genome-wide genetic variation, dietary and physical activity information, and elucidate the pathophysiological pathways that underlie metabolic decline leading to type 2 diabetes.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2014 - 2018

Research Categories:

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