Assessing the Burden of Diabetes by Type in Children, Adolescents and Young Adults (DiCAYA) – Component B (18 to <45 yrs)
The primary goal of the network is to modernize diabetes surveillance efforts to capitalize on large-volume, electronic health record data streams to provide accurate, timely, cost-effective, granular, and representative indicators of diabetes prevalence and incidence. We aim to monitor overall trends and trends within subgroups (e.g., age, sex, diabetes type, and geographic area).
Principal Investigator:Kristi Reynolds, PhD, MPH
Funding Source:Centers for Disease Control and Prevention (CDC)
Funding Years:2020 - 2025
Beta Cell Restoration through Fat Migation
The major goal of this project is to develop approaches that can arrest or reverse progressive Beta-cell disease.
Principal Investigator:Anny Hui Xiang, PhD, MS
Funding Source:Nat'l Inst of Diab & Digestive & Kidney
Comparison of type 2 diabetes pharmacotherapy regimens using targeted learning
The multi-center study will compare newer classes of drugs with older, lower-cost medications, and take a close look at whether the benefits and harms differ between patients who are at low risk or high risk of developing heart problems. The study will also look at whether benefits and harms differ based on the patient’s age, sex, race or ethnicity, heart and kidney function, or other health problems. The findings will help patients with type 2 diabetes and their doctors make more personalized medication treatment decisions.
CV Benefits and Safety of Glucose-Lowering Therapies in Adults with Diabetes
The primary goal of this study is to assess the impact of specific glucose-lowering strategies on cardiovascular events and on mortality in order to identify whether some glucose-lowering strategies confer more cardiovascular benefit than others.
Genetics of Beta Cell Failure in Mexican Americans: Phase II (Beta Gene II)
This application is proposed to call back ~400 individuals in our previous cross-sectional BetaGene cohort study (NIDDK 61628) and re-test them for phenotypes. Analysis will be conducted to determine which genes and how they interact with each other to impact the longitudinal changes in beta-cell function and other T2DM related traits.
Impact of Sugary Beverage Taxes on Weight and Health Outcomes after 3-5 Years
This study uses electronic health records to determine the effects of sugary beverage taxes initiated in 4 Northern California cities compared with control cities in Northern and Southern California. Outcomes include weight change trajectories and prevalence of overweight and obesity among children and adults, and incidence of diabetes among adults with prediabetes. Pre-specified sub-analyses include examining differences by race/ethnicity, age groups, and neighborhood socioeconomic status.
Physiologic Consequence of Genetic Variation (BetaGene III)
The over-arching goal of this study is to assess the physiologic effect of genetic variation in humans and determine how variation in genes alters physiologic processes to contribute to diabetes pathogenesis.
Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site
The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)
Randomized Trial of Exercise Promotion in Primary Care (EPPC)
EPPC is testing the effects of a 2-year motivational interview, telephone-based intervention on increasing moderate to vigorous physical activity among participants with diabetes and prediabetes.
Randomized Trial of Exercise Promotion In Primary Care (EPPC)
To determine the feasibility of a primary care based, telephone counseling physical activity behavioral intervention for diabetics and prediabetics.
Risk Trajectory of Comorbidities Across Natural History of Diabetes
The goal of this study is to examine the long-term development of complications over the course of type 2 diabetes and estimate the incidence of complications including cardiovascular disease, chronic kidney disease, end-stage renal disease, neuropathy, diabetic retinopathy to inform strategies to reduce the burden of type 2 diabetes complications.
SEARCH for Diabetes in Youth Cohort (Follow-Up) Study
The Economic Benefits of Triglyceride Lowering Among Patients with Diabetes and Severe Hypertriglyceridemia
The overall goal of this non-interventional study is to analyze the economic impact of triglyceride lowering and to determine whether this differs among patients who did and did not receive therapy to intentionally lower triglycerides.
The Role of Adipokines in Glucose Regulation and Metabolic Decline
This project measured a large panel of pro- and anti-inflammatory adipokines in existing blood samples collected from BetaGene I and II study participants, combine these data with genome-wide genetic variation, dietary and physical activity information, and elucidate the pathophysiological pathways that underlie metabolic decline leading to type 2 diabetes.