Kidney Diseases studies

Chronic kidney disease continues to increase in the United States, contributing to other various illnesses and often death. Our researchers study determinants and outcomes of chronic kidney disease, as well as disparities in its incidence among certain populations. Our goal is to identify points at which interventions may be tested, in hopes of decreasing the incidence of and complications from the disease.

Development of a CKD Discordance Index to Identify High Healthcare Utilization

The goals of this pilot project are to develop a chronic kidney disease (CKD) discordance index defined by the presence of chronic conditions and treatments that oppose, contradict, or complicate CKD treatment or worsen kidney function in a subsample of CKD patients from KPSC

Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Institute on Aging (NIA)

Funding Years:

2017 - 2018

Kidney Function Decline in Patients with CKD and Untreated Hepatitis C Infection

Studies evaluating the role of hepatitis C viral (HCV) infection on the progression of CKD are few and conflicting. Therefore, we evaluated the association of untreated HCV on kidney function decline in patients with stage 3-5 CKD.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2014 - 2017

Research Categories:

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Optimizing Atrial Fibrillation Management in Chronic Kidney Disease

Atrial fibrillation affects ~25% of patients with kidney disease and is associated with poor clinical outcomes. It remains unknown whether standard therapies for atrial fibrillation are effective and safe in patients with chronic kidney disease. The overall goal of this proposal to study the receipt, safety and efficacy of medications and procedures used in the treatment of atrial fibrillation in patients with kidney disease.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Heart, Lung, and Blood Institute (NHLBI)

Funding Years:

2019 - 2023

Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2015 - 2021

Risk Trajectory of Comorbidities Across Natural History of Diabetes

The goal of this study is to examine the long-term development of complications over the course of type 2 diabetes and estimate the incidence of complications including cardiovascular disease, chronic kidney disease, end-stage renal disease, neuropathy, diabetic retinopathy to inform strategies to reduce the burden of type 2 diabetes complications.

Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2018 - 2020