Child and Adolescent Health studies

Child and adolescent health includes a wide range of chronic and acute physical and mental health conditions. Our research focuses on the prevention, screening, and treatment of disease. We also examine quality of life and quality of care among children and adolescents with conditions such as diabetes, asthma, cancer, and obesity, as well as behavioral, developmental, and mental health conditions.

Assessing the Relationship between Parental Activation and Obesity-related Health Behaviors among Overweight and Obese Low-income Racial/Ethnic Minority Young Patients

The goal of this study is to determine the association between parental activation and obesity-related health behaviors in overweight/obese youth from low-income or racial/ethnic minority background.

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

Kaiser Permanente and Johns Hopkins Medicine Research Collaboration Committee

Funding Years:

2017 - 2018

Chronic Health Problems in Survivors of Adolescent and Young Adult Cancer

The goal of this project is to evaluate the long-term health outcomes, including mortality, second cancer and comorbidities among survivors of adolescent and young adult cancer. The magnitude of risk increase of specific late effects associated with specific cancer therapeutic exposure will also be characterized.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

American Cancer Society

Funding Years:

2015 - 2019

Effects of air pollution and gestational diabetes on autism

The proposal will gather preliminary biomarker data in newborns in response to air pollution and gestational diabetes exposure in-utero

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institute of Environmental Health Sciences/NIH/DHHS (NIEHS)

Funding Years:

2017

Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2015 - 2020

Post-licensure observational safety surveillance study of quadrivalent meningococcal ACWY conjugate vaccine

This study is an observational post-marketing safety study required by the United States Food and Drug Administration (FDA). The primary objective of this study is to describe medical events that require emergency room visit or hospitalization in 6 months following MenACWY-CRM vaccination in children 2-23 months of age in a health maintenance organization (HMO) in the United States.

Principal Investigator:

Hung Fu Tseng, PhD, MPH

Funding Source:

Novartis Vaccines and Diagnostics, Inc.

Funding Years:

2014 - 2018

Risk of Cancer in Childhood and Adolescence Associated with Medical Imaging

The goal of this study it to evaluate patterns of medical imaging associated with cumulative exposure to radiation (CT, nuclear medicine, fluoroscopy, angiography, and radiography), and subsequent risk of childhood cancers.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2015 - 2020

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study

The HAPO Follow-up Study will recruit from the cohort of women and their offspring who participated in the original HAPO Study to test the hypothesis that hyperglycemia in pregnancy, less severe than overt diabetes, is independently associated with increased risk of adverse childhood and maternal outcomes 8-12 years later. The general aim of the study is to obtain measures of adiposity, glucose, insulin sensitivity and secretion, lipids, inflammation and blood pressure in 7,000 HAPO mother-offspring (aged 8-12) pairs of multiple ethnic/race groups from ten of the original HAPO field centers. (RO1DK061628)

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2012 - 2017

Trajectories of Physical Activity and Sedentary Time in Adolescent/Young Women (TAAG 3)

The major goals of this trial are to determine the effectiveness of a school and community-linked physical activity intervention to reduce the decline in physical activity in young women, a cohort who have been followed since middle school.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

Kaiser Permanente and Johns Hopkins Medicine Research Collaboration Committee

Funding Years:

2017 - 2018