Women's Health studies

We examine a broad range of health issues affecting women, covering preventive care, disease screening and treatment, pregnancy and childbirth, health equity, and service delivery. Current studies focus on osteoporosis, breast cancer survivorship, and the relationship between pregnancy and other health issues such as multiple sclerosis.

A prospective cohort analysis of atypical femur fractures (AFF) in women from Kaiser Permanente Southern California (KPSC): identification of risk factors and construction of risk prediction models

The goals of this study are to develop multivariate risk prediction models to predict the 2-year risk of atypical femur fractures and 2-year risk of hip fracture. A secondary goal is to create a simple clinical tool that will allow clinicians and patients to estimate the risk of both types of fractures.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2016 - 2017

An Intervention Study of Reminder Letter for Gardasil Regimen Completion

The goal of this randomized intervention study is to evaluate the effectiveness of a quarterly mailing intervention on human papillomavirus vaccine three-dose regimen completion.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Merck & Co., Inc.

Funding Years:

2012 - 2016

Antidepressants and Breast Cancer Pharmacoepidemiology

This study examines drug interactions between tamoxifen and antidepressants in nearly 23,000 breast cancer survivors diagnosed with early stage disease in the two largest health plans in California.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2010 - 2014

Boostrix immunization in pregnant women

The goal of the Boostrix study is to examine pre-specified pregnancy-related adverse events in a cohort of women vaccinated with Boostrix at 27 weeks gestation or beyond compared to a matched historical unvaccinated control group.

Principal Investigator:

Hung Fu Tseng, PhD, MPH

Funding Source:

GlaxoSmithKline, LLC

Funding Years:

2017 - 2021

Incidence and trend of ectopic pregnancy 2008-2017: a population-based study

Examining the recent trends in ectopic pregnancy among women of childbearing ages.

Principal Investigator:

Darios Getahun, MD, PhD, MPH

Funding Source:

Bayer Pharmaceuticals Corporation

Funding Years:

2018 - 2019

Menveo Pregnancy Registry Study

The objective of the Menveo Pregnancy Registry is to evaluate pregnancy outcomes among women immunized with the Menveo vaccine within 28 days prior to conception or at any time during pregnancy. The primary outcomes of interest include major congenital malformation, preterm birth, and low birth weight. Other pregnancy outcomes will be collected, including spontaneous abortions and stillbirths.

Principal Investigator:

Hung Fu Tseng, PhD, MPH

Funding Source:

GlaxoSmithKline, LLC

Funding Years:

2015 - 2018

Moderate Hypertension in Pregnancy: Safety and Effectiveness of Treatment

Evaluating the effect of treating mild-to-moderate hypertension in pregnancy, compare the risks of clinically important outcomes with different medications, and determine whether the benefits and risks vary by maternal race/ethnicity or obesity status.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Institute of Child Health and Human Development (NICHD)

Funding Years:

2015 - 2019

Prenatal Antibiotic Use and Body Weight in Children

The goal of this study is to examine the potential relationship between antibiotic use during pregnancy and pediatric weight problems.

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2017 - 2019

Sleep Inflammation and Depression Occurrence in Breast Cancer Survivors (STRIVE1)

The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.

Site Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2012

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study

The HAPO Follow-up Study will recruit from the cohort of women and their offspring who participated in the original HAPO Study to test the hypothesis that hyperglycemia in pregnancy, less severe than overt diabetes, is independently associated with increased risk of adverse childhood and maternal outcomes 8-12 years later. The general aim of the study is to obtain measures of adiposity, glucose, insulin sensitivity and secretion, lipids, inflammation and blood pressure in 7,000 HAPO mother-offspring (aged 8-12) pairs of multiple ethnic/race groups from ten of the original HAPO field centers. (RO1DK061628)

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2012 - 2017