As a research center embedded within Kaiser Permanente’s large and dynamic health care system, our investigators have a unique opportunity to apply scientific expertise to real-world clinical problems, translate findings into practice, and share what we learn with the broader community.
Dr. Joan Ryoo is a radiation oncologist at the Kaiser Permanente Los Angeles Medical Center. Her research interests focus on the quality of cancer care in integrated health care systems, including the Veterans Health Administration and Kaiser Permanente. During her residency, she worked with the Department of Research & Evaluation to develop a natural language processing algorithm to identify patients with brain metastases who are not reliably captured in the tumor registry. This research ...
Over the years, clinical trials have led to amazing advances in treatment—even cures—for devastating illnesses. William Towner, MD, FACP, FIDSA, regional physician director for clinical trials, describes how trials at Kaiser Permanente contribute to the development of more effective and safer treatments for diseases such as HIV, hepatitis C, cancer, and more. (2:15)
For carefully selected patients, receiving advanced-level care at home after heart failure may be just as safe and effective as staying in the hospital, a new Kaiser Permanente Southern California study shows. The study, published on July 16, 2026, in JAMA Network Open, examined adults hospitalized for acute heart failure. Researchers compared patients who continued ...
A respiratory syncytial virus vaccine given to older adults remained highly effective at preventing severe illness over 2 RSV seasons, according to a Kaiser Permanente Southern California study. The study offers real-world evidence that the bivalent RSVpreF vaccine continued to protect adults 60 and older from RSV-related hospitalizations and emergency department visits well beyond the ...
When Chance Shipley was finishing high school in Southern California, baseball defined his future. A pitcher with a college scholarship, he was training for the transition to collegiate athletics when he became seriously ill during winter break in December 2019. He was vomiting, exhausted and noticed blood in his urine. At first, he said nothing. ...
A Kaiser Permanente study of nearly 8,000 men shows that in mid- to late 2024, mpox was far more common among men who have sex with men than previously thought. Individuals without symptoms accounted for most infections and likely played a prominent role in transmission, contrary to prior assumptions that people had to be symptomatic ...
Taking doxycycline after sex helped prevent chlamydia and syphilis, but its ability to prevent gonorrhea faded over time as drug‑resistant strains became more common, according to new research. The findings show both the benefits and limits of a prevention strategy now widely used by patients, clinicians, and public health programs to prevent sexually transmitted infection ...
From inspiring patient stories to research that’s shaping the future of care, the latest IMPACT newsletter highlights the power of clinical trials and innovation across Kaiser Permanente Southern California. Read how a clinical trial helped a young pitcher return to baseball, learn how researchers are expanding access to sight-saving treatments, and meet the dedicated nurses helping patients navigate research with compassion and confidence.
You’ll also find new studies on mpox transmission, doxyPEP and sexually transmitted infections, diabetes self-management education, and restaurant portion sizes, along with highlights from the 2025 Annual Report.
The Division of Clinical Trials Research advances medical innovation by supporting evaluation of new drugs, therapies, and devices to prevent and treat health problems. Our physician investigators work with cooperative groups and industry sponsors to conduct clinical trials for investigational drugs, biologics, and devices. In addition, the division develops pragmatic trials that help answer questions about care delivery.
The region has clinical trials programs in oncology (adult, gynecologic, pediatric, and surgical/radiation oncology), urology, gynecology, neurology, dermatology, metabolic diseases, nephrology, ophthalmology, infectious disease, cardiology, hepatology, vascular surgery, and rheumatology. Clinical trials staff support trials at medical centers and medical office buildings throughout the Kaiser Permanente Southern California Region.