As a research center embedded within Kaiser Permanente’s large and dynamic health care system, our investigators have a unique opportunity to apply scientific expertise to real-world clinical problems, translate findings into practice, and share what we learn with the broader community.
Dr. Raymond H. Chen is a senior cardiac surgeon and assistant chief of the Regional Department of Cardiac Surgery for the Southern California Permanente Medical Group. Dr. Chen was 1 of the 4 inaugural members of the Clinician Investigator Program. Before joining the Southern California Permanente Medical Group, Dr. Chen’s research interests included the role of cellular rejection in a cardiac xenotransplantation model and the mechanisms of chronic rejection in human cardiac grafts. He developed ...
Over the years, clinical trials have led to amazing advances in treatment—even cures—for devastating illnesses. William Towner, MD, FACP, FIDSA, regional physician director for clinical trials, describes how trials at Kaiser Permanente contribute to the development of more effective and safer treatments for diseases such as HIV, hepatitis C, cancer, and more. (2:15)
When Chance Shipley was finishing high school in Southern California, baseball defined his future. A pitcher with a college scholarship, he was training for the transition to collegiate athletics when he became seriously ill during winter break in December 2019. He was vomiting, exhausted and noticed blood in his urine. At first, he said nothing. ...
A Kaiser Permanente study of nearly 8,000 men shows that in mid- to late 2024, mpox was far more common among men who have sex with men than previously thought. Individuals without symptoms accounted for most infections and likely played a prominent role in transmission, contrary to prior assumptions that people had to be symptomatic ...
Taking doxycycline after sex helped prevent chlamydia and syphilis, but its ability to prevent gonorrhea faded over time as drug‑resistant strains became more common, according to new research. The findings show both the benefits and limits of a prevention strategy now widely used by patients, clinicians, and public health programs to prevent sexually transmitted infection ...
A large study conducted within Kaiser Permanente Southern California found that people with type 2 diabetes who primarily received diabetes self-management education and support were more likely to achieve healthy blood sugar levels than those whose care focused mainly on physician visits. “For people living with type 2 diabetes, this study shows that actively participating ...
This week, Nurses Week (May 6-12, 2026), we honor all the nurses who work within the Department of Research & Evaluation, who are a vital part of our research. Here we highlight Beatriz Alviso, RN, PHN, BSN who works in the Division of Health Services Research & Implementation Science. What is your background? I grew up ...
The latest IMPACT newsletter highlights Kaiser Permanente research and its real-world relevance. This issue explores why less frequent MS treatment may be just as effective, how staying active during pregnancy supports a healthier postpartum weight, and what new studies reveal about wildfire smoke risks. You’ll also find research on heart disease risk prediction across Asian ethnicities and a Q&A with Dr. Hui Zhou, reflecting on science, service, and being mom to this year’s Rose Queen.
The Division of Clinical Trials Research advances medical innovation by supporting evaluation of new drugs, therapies, and devices to prevent and treat health problems. Our physician investigators work with cooperative groups and industry sponsors to conduct clinical trials for investigational drugs, biologics, and devices. In addition, the division develops pragmatic trials that help answer questions about care delivery.
The region has clinical trials programs in oncology (adult, gynecologic, pediatric, and surgical/radiation oncology), urology, gynecology, neurology, dermatology, metabolic diseases, nephrology, ophthalmology, infectious disease, cardiology, hepatology, vascular surgery, and rheumatology. Clinical trials staff support trials at medical centers and medical office buildings throughout the Kaiser Permanente Southern California Region.