About Our Program

As a research center embedded within Kaiser Permanente’s large and dynamic health care system, our investigators have a unique opportunity to apply scientific expertise to real-world clinical problems, translate findings into practice, and share what we learn with the broader community.

Featured Scientist

Dr. Nigel Gupta headshot
Nigel Gupta, MD
Principal Investigator
Los Angeles
Cardiac Electrophysiology
Clinical.Trials@kp.org

Dr. Nigel Gupta is a cardiologist and electrophysiologist and a principal investigator for clinical trials at the Kaiser Permanente Los Angeles Medical Center. His clinical trials participation includes a worldwide trial to evaluate the safety and effectiveness of a left atrial appendage closure device for patients with atrial fibrillation and a trial evaluating the safety and performance of ventricular defibrillation leads. Dr. Gupta is also an investigator in the federally funded National Cardiovascular ...

Featured Video

Advancing treatments through clinical trials

Over the years, clinical trials have led to amazing advances in treatment—even cures—for devastating illnesses. William Towner, MD, FACP, FIDSA, regional physician director for clinical trials, describes how trials at Kaiser Permanente contribute to the development of more effective and safer treatments for diseases such as HIV, hepatitis C, cancer, and more. (2:15)

News

Featured Image of News Story Titled: Younger adults respond to colorectal cancer screening outreach

Younger adults respond to colorectal cancer screening outreach

The updated national colorectal cancer screening guidelines that recommend screening begin at age 45 — rather than 50 — can benefit younger adults, a new Kaiser Permanente study found. The study was published October 22, 2024, in Annals of Internal Medicine. It included 267,732 Kaiser Permanente members in Northern California, Washington, and Colorado ages 45 ...

Opioid use among breast cancer survivors can increase risk of falls and fractures

Breast cancer survivors commonly continue to use opioid pain killers after their cancer treatment is complete. A new Kaiser Permanente study shows that this can increase their risk of falls and bone fractures, lung problems, and cardiovascular conditions. The study was published in October 2024 in The Oncologist. A cancer epidemiologist partnered with a breast ...

Five questions for … Dr. Heidi Brown

Heidi Brown, MD, MAS, is a urogynecologist and a dissemination and implementation scientist who joined the Department of Research & Evaluation in August 2023. Her research focuses on improving access to effective solutions for pelvic floor disorders such as bladder and bowel incontinence and pelvic organ prolapse. She uses community engagement, user-centered design, and iterative ...

No increased risk associated with flu vaccines given in closely spaced pregnancies

Monitoring of about 45,000 pregnant people receiving flu vaccines in each of 2 successive pregnancies showed no increased risk of side effects or health issues, according to a Kaiser Permanente study published September 19, 2024, in JAMA Network Open. “Our study’s findings support recommendations to give flu vaccinations to pregnant persons even if they received ...

Beta blockers not all the same for patients with heart failure and CKD

A Kaiser Permanente Southern California study showed that 1 heart-failure medication worked best among the 3 most commonly used to prevent illness and disease among patients with chronic kidney disease and heart failure. “Beta blockers save lives in heart failure patients, but we wanted to see how this worked among patients who also had chronic ...

Events

Featured Division

Clinical Trials Research

Our physician investigators conduct clinical trials in communities across Southern California, from Bakersfield to San Diego.

The Division of Clinical Trials Research advances medical innovation by supporting evaluation of new drugs, therapies, and devices to prevent and treat health problems. Our physician investigators work with cooperative groups and industry sponsors to conduct clinical trials for investigational drugs, biologics, and devices. In addition, the division develops pragmatic trials that help answer questions about care delivery.

The region has clinical trials programs in oncology (adult, gynecologic, pediatric, and surgical/radiation oncology), urology, gynecology, neurology, dermatology, metabolic diseases, nephrology, ophthalmology, infectious disease, cardiology, hepatology, vascular surgery, and rheumatology. Clinical trials staff support trials at medical centers and medical office buildings throughout the Kaiser Permanente Southern California Region.