Bone Health and Orthopedics studies
A prospective cohort analysis of atypical femur fractures (AFF) in women from Kaiser Permanente Southern California (KPSC): identification of risk factors and construction of risk prediction models
The goals of this study are to develop multivariate risk prediction models to predict the 2-year risk of atypical femur fractures and 2-year risk of hip fracture. A secondary goal is to create a simple clinical tool that will allow clinicians and patients to estimate the risk of both types of fractures.
Femur Fracture Outcomes Associated with Bisphosphonate Use
The goals of this study are to examine the association between long-term bisphosphonate use patterns and subsequent risk of major osteoporotic fracture and to estimate the association between long-term bisphosphonate use patterns and subsequent risk of atypical femur fracture.
Site Principal Investigator:Annette L. Adams, PhD, MPH
Funding Source:National Institute on Aging (NIA)
Funding Years:2015 - 2018
Pre-operative Assessment of Fusion-related Bone Failure
The objective of this case-cohort study is to apply biomechanical computed tomography (BCT) analysis and virtual stress testing (VST) to pre-operative CT scans for a cohort of candidates for spine-fusion surgery to predict clinical/surgical outcomes such as pedicle screw failure, endplate subsidence, proximal junctional failure, and overall surgery failure. We will be testing the hypothesis that VST indices can predict surgical failure independent of other known pre-operative risk factors or bone mineral density.
Principal Investigator:Annette L. Adams, PhD, MPH
Funding Source:National Institutes of Health (NIH)
Funding Years:2018 - 2019
Retrospective Cohort Study of Risk of Hip Fractures Associated with High Dose, Long-term Proton Pump Inhibitor (HD-PPI) Use and Cytochrome P450 Pharmacogenomics
The main goals of this study are to conduct two related cohort studies intended to address questions related to the association between PPI and HD-PPI use in a setting of complex medication usage patterns and to conduct a pharmacogenetics study exploring potential modification of the relationship between PPI use and hip fracture risk by CYP2C19 genotype.
Skeletal Outcomes in Primary Hyperparathyroidism
The aim of the study is to retrospectively compare fracture rates and BMD changes in patients with PHPT who have received the following types of treatment: observation, bisphosphonate therapy, surgery, or both surgery and bisphosphonate therapy.
Studying the relationship of hyponatremia on bone disease, fractures, and fall risk
A cross sectional and longitudinal study that seeks to establish or determine a relationship between hyponatremia and bone density disorders (osteoporosis); hyponatremia and vertebral fractures; hyponatremia and risk of hip fractures.