Diabetes studies

The incidence of type 2 diabetes is increasing globally as the prevalence of obesity increases, and the incidence of type 1 diabetes is also on the rise. Patients are being diagnosed with both types of diabetes at younger ages. Our researchers study the genetics, prevention, treatment, quality of care, and health outcomes of patients with diabetes.

Beta Cell Restoration through Fat Migation

The major goal of this project is to develop approaches that can arrest or reverse progressive Beta-cell disease.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

Nat'l Inst of Diab & Digestive & Kidney

Funding Years:

2011

Care of Mental, Physical, and Substance Use Syndromes (COMPASS)

KPSC is one of nine sites throughout the country funded by an Innovation Award from the Centers of Medicare and Medicaid to implement a coordinated care model for depressed patients with cardiovascular disease. We have the following goals for this project: 1. To implement in three stages a multiple condition collaborative care management model in primary care clinics of care systems in states. 2. To demonstrate that this model improves care quality, patient experience and health, provider satisfaction, and total healthcare costs for the Medicare and Medicaid patients with the targeted conditions. 3. To develop role descriptions and training for the two new types of workers required for this model – care managers and care consultants. 4. To identify the costs and payment models needed by care systems to sustain and spread this care model.

Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

Institute for Clinical Systems Improvement (ICSI)

Funding Years:

2012 - 2015

CV Benefits and Safety of Glucose-Lowering Therapies in Adults with Diabetes

The primary goal of this study is to assess the impact of specific glucose-lowering strategies on cardiovascular events and on mortality in order to identify whether some glucose-lowering strategies confer more cardiovascular benefit than others.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Heart, Lung, and Blood Institute (NHLBI)

Funding Years:

2014 - 2018

Disparities in Progression to Renal Replacement Therapy

This retrospective cohort study will explore the reasons for the increased incidence of end-stage renal disease in African Americans and Hispanics by focusing on quality of care for diabetes, hypertension, and chronic kidney disease.

Principal Investigator:

Stephen F. Derose, MD, MSHS

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2009 - 2013

Genetics of Beta Cell Failure in Mexican Americans: Phase II (Beta Gene II)

This application is proposed to call back ~400 individuals in our previous cross-sectional BetaGene cohort study (NIDDK 61628) and re-test them for phenotypes. Analysis will be conducted to determine which genes and how they interact with each other to impact the longitudinal changes in beta-cell function and other T2DM related traits.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2009 - 2014

Glargine Insulin and Risk of Cancer in Cohort of Patients with Diabetes

The goal of this project was to understand the cancer risks associated with use of glargine, an insulin medication. This study compared the risk of several types of cancer among individuals with diabetes who used glargine to those using NPH, another type of insulin.

Site Principal Investigator:

Kim N. Danforth, ScD, MPH

Funding Source:

Sanofi-Aventis U.S. LLC

Funding Years:

2010 - 2013

PCORnet Bariatric Study

This study is designed to address the following aims in over 30 clinical sites participating in the national Patient-Centered Outcomes Research Network (PCORnet) Bariatric Study: Aim 1: To what extent does weight loss and weight regain differ across bariatric surgical procedures (Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding) at 1, 3, and 5 years? Aim 2: To what extent does bariatric surgery lead to improvements in diabetes risk at 1, 3, and 5 years? Aim 3: What is the frequency of adverse events following different bariatric surgical procedures at 1, 3, and 5 years? Aim 4: To elicit patient preferences around the risks and benefits regarding the choice of (a) whether to undergo bariatric surgery; (b) which bariatric procedure to utilize; and (c) follow-up care after bariatric surgery.

Site Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

Patient-Centered Outcomes Research Institute (PCORI)

Funding Years:

2016 - 2018

Physiologic Consequence of Genetic Variation (BetaGene III)

The over-arching goal of this study is to assess the physiologic effect of genetic variation in humans and determine how variation in genes alters physiologic processes to contribute to diabetes pathogenesis.

Site Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

Nat'l Inst of Diab & Digestive & Kidney

Funding Years:

2015

Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2015 - 2020

Randomized Trial of Exercise Promotion In Primary Care (EPPC)

To determine the feasibility of a primary care based, telephone counseling physical activity behavioral intervention for diabetics and prediabetics.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2014 - 2016

SEARCH Nutrition Ancillary Study 2 (SNAS2)

The goal of SNAS2 is to examine associations of nutritional factors with 1) markers of subclinical cardiovascular disease; 2) prevalence and severity of retinopathy; and 3) prevalence, severity and incidence of diabetic kidney disease in youth with type 1 diabetes and type 2 diabetes. (2R01DK077949)

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2014 - 2018

The Economic Benefits of Triglyceride Lowering Among Patients with Diabetes and Severe Hypertriglyceridemia

The overall goal of this non-interventional study is to analyze the economic impact of triglyceride lowering and to determine whether this differs among patients who did and did not receive therapy to intentionally lower triglycerides.

Site Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

AstraZeneca

Funding Years:

2015 - 2016

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study

The HAPO Follow-up Study will recruit from the cohort of women and their offspring who participated in the original HAPO Study to test the hypothesis that hyperglycemia in pregnancy, less severe than overt diabetes, is independently associated with increased risk of adverse childhood and maternal outcomes 8-12 years later. The general aim of the study is to obtain measures of adiposity, glucose, insulin sensitivity and secretion, lipids, inflammation and blood pressure in 7,000 HAPO mother-offspring (aged 8-12) pairs of multiple ethnic/race groups from ten of the original HAPO field centers. (RO1DK061628)

Site Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2012 - 2017

The Role of Adipokines in Glucose Regulation and Metabolic Decline

This project measured a large panel of pro- and anti-inflammatory adipokines in existing blood samples collected from BetaGene I and II study participants, combine these data with genome-wide genetic variation, dietary and physical activity information, and elucidate the pathophysiological pathways that underlie metabolic decline leading to type 2 diabetes.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2014 - 2018