Sleep Disorders studies
Approaches to Genetic Heterogeneity of Obstructive Sleep Apnea
The main goal of this study is to use state of the art approaches to identify relevant genes based on a very large sample of patients with Obstructive Sleep Apnea (OSA), a common disorder with multiple adverse consequences. It is known that OSA has a genetic basis, but to date no convincing gene variants have been identified. This study uses OSA obtained from multiple institutions in the United States. It is the largest study ever proposed for identifying genes for this common sleep disorder.
Principal Investigator:Corinna Koebnick, PhD, MSc
Funding Source:National Heart, Lung, and Blood Institute (NHLBI)
Funding Years:2016 - 2020
Biobehavioral Vulnerability to Accelerated Aging in Breast Cancer Survivors
The aim of this project is to examine cellular and genomic markers of inflammation, telomere erosion, telomere length, and microarray data of 300 breast cancer survivors and comparison women who are enrolled in the KPSC-UCLA collaborative STRIVE1 and STRIVE2 studies.
Site Principal Investigator:Reina Haque, PhD, MPH
Funding Source:American Cancer Society
Funding Years:2016 - 2019
PAP Therapy and Acute Care Utilization in a Large Integrated Health System
This study will determine if clinically diagnosed sleep apnea for which a PAP machine has been prescribed is associated with a reduction in expensive acute care utilization and if significant variation in utilization exists to suggest treatment disparities.
Principal Investigator:Stephen F. Derose, MD, MSHS
Funding Source:ResMed Foundation
Funding Years:2013 - 2016
Sleep Inflammation and Depression Occurrence in Breast Cancer Survivors (STRIVE1)
The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.