Health Policy studies

As a national leader in health care, Kaiser Permanente is a major force in the discussion about U.S. health care. Our research team joins public policy discussions and contributes expertise to national advocacy groups and government advisory committees. We also share research results with others to help them provide opportunities for healthier living in their communities.

Antimicrobial resistant E. coli before and after California Senate bill 27 (ARES): a natural experiment

This study will allow us to comprehensively evaluate the casual link between food animal use of antibiotics, food product contamination, and human disease. These findings will inform future policy interventions towards a potentially modifiable source of AMR to reduce the burden on human populations nationally and globally.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2017 - 2022

Effects of Medical Products on Suicidal Ideation and Behavior in Serious Mental Illness

Reducing risk of suicidal behavior is an urgent public health priority. Suicide accounted for approximately 45,000 deaths in the United States in 2016. While most major causes of death have steadily declined, suicide mortality in the US has increased by over 25% in the past 15 years, with greater increases in young people. Increasing rates of suicidal behavior are intertwined with prescription opioid use and opioid overdose. Traditional clinical trials will not be able to enroll large enough nor generalizable enough samples of patients to adequately inform regulation regarding these issues. We propose a comprehensive program of infrastructure development and methods development to support future generation of real-world evidence addressing these critical gaps. The project team will include health systems and embedded research organizations with deep expertise in stakeholder engagement, medical informatics, data science, clinical epidemiology, biostatistics, pragmatic clinical trial methods, implementation science, and innovations in care delivery. This program will be embedded in 4 integrated health systems serving a combined population of approximately 10 million members. This work will be conducted in collaboration with health system and patient/family stakeholders, to assure that methods and evidence developed will actually address real-world questions.

Site Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

Food and Drug Administration (FDA)

Funding Years:

09/30/2018 - 09/30/2021

Extended Herpes Zoster Vaccine Effectiveness in a Health Maintenance Organization

The objectives of this study are to conduct a retrospective cohort study to evaluate the long-term effectiveness of the zoster vaccine for preventing HZ and PHN among persons 60 years of age or older. Understanding the long-term duration of vaccine effectiveness will be critical for monitoring impact of the zoster vaccination program, as well as for informing policy decisions that the ACIP will face, such as the consideration of a booster dose, and determining the optimum age to begin vaccination.

Principal Investigator:

Hung Fu Tseng, PhD, MPH

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2014 - 2024

GWU/Wellcome 1 Feasibility

To collect preliminary data to support the larger Wellcome grant.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

The George Washington University

Funding Years:

2018 - 2019

Learning from California Senate bill 27: a natural experiment

This study complements an ongoing R01 study to provide more compelling evidence regarding the impact of SB27 by examining all major meat types (chicken, turkey, pork and beef) that may be impacted by the bill. Likewise, we include collection of the frank foodborne pathogens, Salmonella and Campylobacter, to provide additional insights into the potential effectiveness of this policy intervention.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

Wellcome Trust

Funding Years:

2018 - 2022