Bone Health and Orthopedics studies

We work closely with Kaiser Permanente orthopedic surgeons to examine factors related to injuries in patients of all ages. Studies have focused on prevention and treatment of hip fractures, osteoporosis-related injuries, and outcomes associated with total joint replacements and other reconstructive interventions.

A prospective cohort analysis of atypical femur fractures (AFF) in women from Kaiser Permanente Southern California (KPSC): identification of risk factors and construction of risk prediction models

The goals of this study are to develop multivariate risk prediction models to predict the 2-year risk of atypical femur fractures and 2-year risk of hip fracture. A secondary goal is to create a simple clinical tool that will allow clinicians and patients to estimate the risk of both types of fractures.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2016 - 2017

Femur Fracture Outcomes Associated with Bisphosphonate Use

The goals of this study are to examine the association between long-term bisphosphonate use patterns and subsequent risk of major osteoporotic fracture and to estimate the association between long-term bisphosphonate use patterns and subsequent risk of atypical femur fracture.

Site Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

National Institute on Aging (NIA)

Funding Years:

2015 - 2018

Fracture, Osteopenia, and CT Utilization Study (FOCUS Study)

The aim of this study is to validate within a population of KPSC patients the ability of a CT-based Biomechanical CT analysis to identify patients with osteopenia who are at high risk for hip fracture.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2015 - 2017

Fracture, Osteopenia, and CT Utilization Study (FOCUS Study)

The aim of this study is to validate within a population of KPSC patients the ability of a CT-based Biomechanical CT analysis to identify patients with osteopenia who are at high risk for hip fracture.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Amgen, Inc.

Funding Years:

2016 - 2017

Osteoporotic fractures and associated healthcare resource utilization

The primary aim of this cohort study is to assess the downstream effects of fragility fracture, including mortality, recurrent fracture, and health-care resource utilization in the first post-fracture year.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Radius Health, Inc.

Funding Years:

2018 - 2020

Pre-operative Assessment of Fusion-related Bone Failure

The objective of this case-cohort study is to apply biomechanical computed tomography (BCT) analysis and virtual stress testing (VST) to pre-operative CT scans for a cohort of candidates for spine-fusion surgery to predict clinical/surgical outcomes such as pedicle screw failure, endplate subsidence, proximal junctional failure, and overall surgery failure. We will be testing the hypothesis that VST indices can predict surgical failure independent of other known pre-operative risk factors or bone mineral density.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2018 - 2019

Predicting Two Year Risk of Major Osteoporosis-related Fractures

The primary objective of the study is to develop and validate clinical prediction models to estimate the 1-2 year risk of: (1) major osteoporosis-related fractures and (2) osteoporosis-related hip fractures.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Amgen, Inc.

Funding Years:

2014 - 2017

Retrospective Cohort Study of Risk of Hip Fractures Associated with High Dose, Long-term Proton Pump Inhibitor (HD-PPI) Use and Cytochrome P450 Pharmacogenomics

The main goals of this study are to conduct two related cohort studies intended to address questions related to the association between PPI and HD-PPI use in a setting of complex medication usage patterns and to conduct a pharmacogenetics study exploring potential modification of the relationship between PPI use and hip fracture risk by CYP2C19 genotype.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Food and Drug Administration (FDA)

Funding Years:

2014 - 2018

Skeletal Outcomes in Primary Hyperparathyroidism

The aim of the study is to retrospectively compare fracture rates and BMD changes in patients with PHPT who have received the following types of treatment: observation, bisphosphonate therapy, surgery, or both surgery and bisphosphonate therapy.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

University of California, Los Angeles (UCLA)

Funding Years:

2013 - 2019

Studying the relationship of hyponatremia on bone disease, fractures, and fall risk

A cross sectional and longitudinal study that seeks to establish or determine a relationship between hyponatremia and bone density disorders (osteoporosis); hyponatremia and vertebral fractures; hyponatremia and risk of hip fractures.

Principal Investigator:

Annette L. Adams, PhD, MPH

Funding Source:

Otsuka America Pharmaceutical, Inc.

Funding Years:

2015