Molecular Epidemiology studies

Our investigators lead studies of breast, prostate, and AIDS-related cancer using our vast repository of specimens that are obtained during surgery. These studies will help identify the best treatments or determine disease progression for individual patients. Unlike other settings, the specimens obtained from our membership broadly reflect the characteristics of the general Southern California population, in terms of racial, ethnic, and socioeconomic diversity.

Chronic Myelogenous Leukemia and Outcomes of Tyrosine Kinase Inhibitor Therapy

The aim of this investigation initiated retrospective cohort study are to examine long-term health effects in the cohort of CML and determine if health effects vary by drug adherence to TKIs.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

Novartis Pharmaceuticals Corporation

Funding Years:

2013

GWU/Wellcome 1 Feasibility

To collect preliminary data to support the larger Wellcome grant.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

The George Washington University

Funding Years:

2018 - 2019

Learning from California Senate bill 27: a natural experiment

This study complements an ongoing R01 study to provide more compelling evidence regarding the impact of SB27 by examining all major meat types (chicken, turkey, pork and beef) that may be impacted by the bill. Likewise, we include collection of the frank foodborne pathogens, Salmonella and Campylobacter, to provide additional insights into the potential effectiveness of this policy intervention.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

Wellcome Trust

Funding Years:

2018 - 2022

Molecular and Genetic Determinants of non-Hodgkin Lymphoma

The goal of this study is to investigate whether the genetic variation in the human leukocyte antigen and other key a priori genes linked to human leukocyte antigen, including tumor necrosis factor play a role in non-Hodgkin lymphoma prognosis and overall survival.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2012 - 2017

Observational Study of the Epidemiology in Clinical Outcomes of Breast Cancer in Women with BRCA Mutations

This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

AstraZeneca

Funding Years:

2015

PD-1/PD-L1 Blockage Plus Kinase Inhibitor Therapies for B cell Lymphomas

This study aims to explore rational combination therapies aimed at cytoreduction of advanced tumors followed by antibody-mediated immune checkpoint inhibition to stimulate adaptive T cell anti-lymphoma immunity. We will study a large cohort of human diffuse large B cell (DLBCL) samples and utilize syngeneic, immunocompetent mouse lymphoma models that mimic the varied sensitivity of human B cell NHL to kinase inhibitors

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Leukemia and Lymphoma Society

Funding Years:

2013 - 2016