Cancer studies

Our Southern California Cancer Research Program continues to grow, with the initiation of many clinical trials and epidemiological and behavioral studies. Our scientists and clinicians engage in innovative research across the continuum, from etiology, prevention, and treatment to quality of life and survivorship in children and adults. Kaiser Permanente has been awarded a grant by the National Cancer Institute as a member of the National Cancer Institute Community Oncology Program. We also participate in a number of national collaborative groups, including the National Cancer Institute’s Cancer Research Network. See our Cancer Research Program brochure for more information.

A Cohort study of co-morbid conditions and risk of chemotherapy associated febrile neutropenia in patients with selected types of cancers in Kaiser Permanente Southern California

The goal of this study is to examine the association between chronic co-morbid conditions and risk of febrile neutropenia, and grade III and IV neutropenia associated with first cycle chemotherapy.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Amgen, Inc.

Funding Years:

2013 - 2016

A Registry to Improve Care and Research in Lung Cancer Screening

This is an award to demonstrate the feasibility of developing a registry of individuals who undergo lung cancer screening with low-dose CT.

Principal Investigator:

Michael K. Gould, MD, MS

Funding Source:

Cancer Research Network (CRN)

Funding Years:

2014 - 2016

An Examination of Chronic Health Problems of Survivors of Cancer

An Examination of Chronic Health Problems of Survivors of Cancer

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

City Of Hope

Funding Years:

2014 - 2016

Antidepressants and Breast Cancer Pharmacoepidemiology

This study examines drug interactions between tamoxifen and antidepressants in nearly 23,000 breast cancer survivors diagnosed with early stage disease in the two largest health plans in California.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2010 - 2014

Assessing Treatment Patterns and Quality Gaps in Non-Muscle Invasive Bladder Cancer Care

The goal of this study was to understand reasons for the use/non-use of intravesical chemotherapy or immunotherapy following the initial bladder tumor resection among patients with bladder cancer.

Principal Investigator:

Kim N. Danforth, ScD, MPH

Funding Source:

Kaiser Permanente, Southern California

Funding Years:

2013 - 2014

Biobehavioral Vulnerability to Accelerated Aging in Breast Cancer Survivors

The aim of this project is to examine cellular and genomic markers of inflammation, telomere erosion, telomere length, and microarray data of 300 breast cancer survivors and comparison women who are enrolled in the KPSC-UCLA collaborative STRIVE1 and STRIVE2 studies.

Site Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

American Cancer Society

Funding Years:

2016

Cardiovascular toxicity following aromatase inhibitor use

The aim of this cohort is to assess the risk of cardiovascular disease associated with endocrine treatments for breast cancer.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

California Breast Cancer Research Program (CBCRP)

Funding Years:

2013

Chemotherapy Induced Compliances: FN risk in selected regimens

The goal of this observational study is to evaluate the average risk of febrile neutropenia (FN) in patients receiving chemotherapy regimens with previously undefined FN risk.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Amgen, Inc.

Funding Years:

2014 - 2016

Chronic Health Problems in Survivors of Adolescent and Young Adult Cancer

The goal of this project is to evaluate the long-term health outcomes, including mortality, second cancer and comorbidities among survivors of adolescent and young adult cancer. The magnitude of risk increase of specific late effects associated with specific cancer therapeutic exposure will also be characterized.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

American Cancer Society

Funding Years:

2015 - 2019

Chronic Myelogenous Leukemia and Outcomes of Tyrosine Kinase Inhibitor Therapy

The aim of this investigation initiated retrospective cohort study are to examine long-term health effects in the cohort of CML and determine if health effects vary by drug adherence to TKIs.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

Novartis Pharmaceuticals Corporation

Funding Years:

2013

Developing tailored de-implementation strategies to reduce use of low-value cancer care services

The goal of this mixed methods study is to develop and test interventions to reduce use of surveillance biomarkers for early stage breast cancer patients.

Principal Investigator:

Erin E. Hahn, PhD, MPH

Funding Source:

Kaiser Permanente, Southern California

Funding Years:

2014 - 2015

Development of an automated method to capture bladder cancer recurrence and progression for epidemiologic research

The purpose of this study is to develop and validate automated algorithms using natural language processing (NLP) to capture bladder cancer recurrence and progression from free-text pathology, urology, and imaging notes.

Principal Investigator:

Kim N. Danforth, ScD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2019 - 2021

Economic, Epidemiologic and Clinical Burden Associated with Neutropenia and Febrile Neutropenia in Three Cancers

The primary objective of this study is to estimate the resource utilization and direct medical expenditure associated with neutropenia and febrile neutropenia, in Non-Hodgkin’s Lymphoma, Breast cancer and Lung cancer patients. The secondary objective is to determine the trend of incidence of neutropenia with and without fever in Non-Hodgkin’s Lymphoma, Breast cancer and Lung cancer. The study will also describe management patterns and evaluate trend of management patterns for febrile neutropenia. Lastly, we will also estimate the febrile neutropenia specific mortality rate in hospitalized patients by cancer type.

Principal Investigator:

Aniket A. Kawatkar, PhD, MS

Funding Source:

Amgen, Inc.

Funding Years:

2011 - 2015

Glargine Insulin and Risk of Cancer in Cohort of Patients with Diabetes

The goal of this project was to understand the cancer risks associated with use of glargine, an insulin medication. This study compared the risk of several types of cancer among individuals with diabetes who used glargine to those using NPH, another type of insulin.

Site Principal Investigator:

Kim N. Danforth, ScD, MPH

Funding Source:

Sanofi-Aventis U.S. LLC

Funding Years:

2010 - 2013

Kaiser Permanente NCI National Community Oncology Research Program-Cancer Care Delivery Research Program

The specific aim of the Cancer Care Delivery Research portion of this program is to conduct and help design cancer care delivery research within the National Community Oncology Research Program (NCORP

Principal Investigator:

Michael K. Gould, MD, MS

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2014

Molecular and Genetic Determinants of non-Hodgkin Lymphoma

The goal of this study is to investigate whether the genetic variation in the human leukocyte antigen and other key a priori genes linked to human leukocyte antigen, including tumor necrosis factor play a role in non-Hodgkin lymphoma prognosis and overall survival.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2012 - 2017

Observational Study of the Epidemiology in Clinical Outcomes of Breast Cancer in Women with BRCA Mutations

This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

AstraZeneca

Funding Years:

2015

OPATS: Outcomes of Prostate Cancer Androgen Deprivation Therapy Study

The goal is to assess fatal and morbid outcomes up to 15 years following androgen deprivation therapy for men initially diagnosed with localized prostate cancer.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2010 - 2014

PD-1/PD-L1 Blockage Plus Kinase Inhibitor Therapies for B cell Lymphomas

This study aims to explore rational combination therapies aimed at cytoreduction of advanced tumors followed by antibody-mediated immune checkpoint inhibition to stimulate adaptive T cell anti-lymphoma immunity. We will study a large cohort of human diffuse large B cell (DLBCL) samples and utilize syngeneic, immunocompetent mouse lymphoma models that mimic the varied sensitivity of human B cell NHL to kinase inhibitors

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Leukemia and Lymphoma Society

Funding Years:

2013 - 2016

Personalized Risk-Adaptive surveIllance Strategies in cancEr (PRAISE)

The major goals of this project are to develop innovative risk-adaptive models of cancer surveillance for colorectal, chronic myeloid leukemia, and prostate cancer using value-of-information statistical methodology.

Site Principal Investigator:

Erin E. Hahn, PhD, MPH

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2018

Pilot Study of Neutropenia in Cancer Patients with Co-Morbid Conditions

The goal of this study is to evaluate the feasibility of determining the occurrence of neutropenia and febrile neutropenia as well as cancer treatment using electronic medical records.

Principal Investigator:

Chun Chao, PhD, MS

Funding Source:

Amgen, Inc.

Funding Years:

2009

REPRISE 2: Is depression associated with prostate cancer progression?

This study examines if depression and its treatment can affect the course of prostate cancer.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2018

Risk of Cancer in Childhood and Adolescence Associated with Medical Imaging

The goal of this study it to evaluate patterns of medical imaging associated with cumulative exposure to radiation (CT, nuclear medicine, fluoroscopy, angiography, and radiography), and subsequent risk of childhood cancers.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2015 - 2020

Sleep Disturbance, Inflammation & Cellular Aging in Breast Cancer Survivors (STRIVE 2)

The goal of this prospective recruitment study is to evaluate longitudinal differences in the rates of change in inflammation and telomere erosion in breast cancer survivors vs. non-cancer comparison women to determine if such molecular changes are due to cancer biology, or its treatment, or consequences of aging.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2016

Sleep Inflammation and Depression Occurrence in Breast Cancer Survivors (STRIVE1)

The aim of this prospective study is to examine the association between sleep disturbance, cellular and genomic markers of inflammation, and depression occurrence in breast cancer survivors.

Site Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2012

Using Stakeholder Perspectives to Improve Survivorship Care Plan Implementation

The goal of this study is to gain insight and understanding into planned and implemented processes of survivorship care in diverse health care settings.

Principal Investigator:

Erin E. Hahn, PhD, MPH

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2016 - 2017