Obesity studies

The alarming increase of obesity in the United States is associated with many serious health issues for children and adults. We study risk factors, treatment, acute and chronic complications, and pregnancy outcomes associated with obesity. Our pediatric obesity research examines prevention, disparities, and premature illness in children with extreme obesity. Our studies with adults focus on development of effective weight management programs as well as the potential risks and benefits of bariatric surgery.

Effectiveness of Gastric Sleeve vs. Gastric Bypass for Cardiovascular Disease (ENGAGE-CVD)

This study will include only bariatric surgery patients from Kaiser Permanente Southern California and is designed to achieve the following aims: 1) compare the effectiveness of vertical sleeve gastrectomy (VSG) and Roux-en-Y Gastric Bypass (RYGB) in remission of risk factors for cardiovascular disease (CVD) and reduction in overall CVD risk using advanced statistical and econometric techniques.; 2) compare VSG and RYGB surgical safety using similar methods; and 3) understand the treatment effect heterogeneity in remission of CVD risk factors, reduction in overall CVD risk, and safety outcomes for patients with different racial/ethnic backgrounds, sexes, and disease burdens at the time of surgery.

Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

National Heart, Lung, and Blood Institute (NHLBI)

Funding Years:

2016 - 2020

Impact of Bariatric Surgery on Cancer Incidence in Severely Obese Adults

The goal of this project is to estimate the impact of bariatric surgery versus routine non-surgical care on the incidence of cancer (all types) in all severely obese patients (men and women).

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

National Cancer Institute (NCI)

Funding Years:

2014 - 2018

Kaiser Permanente & Strategic Partners Patient Outcomes Research To Advance Learning, (PCORI/PORTAL Network)

The PORTAL network propose to create a cohort of adults who are overweight or obese, including those who have pre-diabetes or diabetes. The cohort development activity will demonstrate that the PORTAL network is able to meet the 10 criteria for a clinical data research network specified by PCORI.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

Patient-Centered Outcomes Research Institute (PCORI)

Funding Years:

2014 - 2015

PCORnet Bariatric Study

This study is designed to address the following aims in over 30 clinical sites participating in the national Patient-Centered Outcomes Research Network (PCORnet) Bariatric Study: Aim 1: To what extent does weight loss and weight regain differ across bariatric surgical procedures (Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding) at 1, 3, and 5 years? Aim 2: To what extent does bariatric surgery lead to improvements in diabetes risk at 1, 3, and 5 years? Aim 3: What is the frequency of adverse events following different bariatric surgical procedures at 1, 3, and 5 years? Aim 4: To elicit patient preferences around the risks and benefits regarding the choice of (a) whether to undergo bariatric surgery; (b) which bariatric procedure to utilize; and (c) follow-up care after bariatric surgery.

Site Principal Investigator:

Karen J. Coleman, PhD, MS

Funding Source:

Patient-Centered Outcomes Research Institute (PCORI)

Funding Years:

2016 - 2018

Prenatal Antibiotic Use and Body Weight in Children

The goal of this study is to examine the potential relationship between antibiotic use during pregnancy and pediatric weight problems. Particular focus is given to infants exposed to intrapartum Group B streptococcus prophylaxis and its impact on a child's body weight.

Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2017 - 2019

Randomized Trial of Exercise Promotion In Primary Care (EPPC)

To determine the feasibility of a primary care based, telephone counseling physical activity behavioral intervention for diabetics and prediabetics.

Principal Investigator:

Deborah Rohm Young, PhD, MBA

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2014 - 2016

The Role of Adipokines in Glucose Regulation and Metabolic Decline

This project measured a large panel of pro- and anti-inflammatory adipokines in existing blood samples collected from BetaGene I and II study participants, combine these data with genome-wide genetic variation, dietary and physical activity information, and elucidate the pathophysiological pathways that underlie metabolic decline leading to type 2 diabetes.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2014 - 2018

Using Computational Approaches to Optimize Asthma Care Management

This project aims to improve the accuracy of computationally identifying high-risk asthma patients, it's assess potential impact on outcomes and to provide automated prediction result explanations for care management.

Site Principal Investigator:

Corinna Koebnick, PhD, MSc

Funding Source:

National Heart, Lung, and Blood Institute (NHLBI)

Funding Years:

2018 - 2022