Kidney Diseases studies

Chronic kidney disease continues to increase in the United States, contributing to other various illnesses and often death. Our researchers study determinants and outcomes of chronic kidney disease, as well as disparities in its incidence among certain populations. Our goal is to identify points at which interventions may be tested, in hopes of decreasing the incidence of and complications from the disease.

Archimedes IndiGO End-Stage Renal Disease Tool Development and Validation

Archimedes IndiGO will be used to predict outcomes for Chronic Kidney Disease and provide an interface for patient management. The accuracy of outcomes prediction will be tested in this study.

Principal Investigator:

Stephen F. Derose, MD, MSHS

Funding Source:

Kaiser Foundation Health Plan, Inc.

Funding Years:

2013 - 2015

Development of a CKD Discordance Index to Identify High Healthcare Utilization

The goals of this pilot project are to develop a chronic kidney disease (CKD) discordance index defined by the presence of chronic conditions and treatments that oppose, contradict, or complicate CKD treatment or worsen kidney function in a subsample of CKD patients from KPSC

Principal Investigator:

Kristi Reynolds, PhD, MPH

Funding Source:

National Institute on Aging (NIA)

Funding Years:

2017 - 2018

Disparities in Progression to Renal Replacement Therapy

This retrospective cohort study will explore the reasons for the increased incidence of end-stage renal disease in African Americans and Hispanics by focusing on quality of care for diabetes, hypertension, and chronic kidney disease.

Principal Investigator:

Stephen F. Derose, MD, MSHS

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2009 - 2013

Electronic Clinical Surveillance to Measure and Improve Safety in Ambulatory Care

This study seeks to determine the incidence of three types of medical errors and the underlying factors that contribute to them within the ambulatory care settings of a large, diverse integrated delivery system. Specifically, we are studying delayed diagnosis of kidney disease (diagnostic error), use of contraindicated medications among patients with a history of falls (treatment error), and lack of annual monitoring for patients on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (preventive error).

Principal Investigator:

Kim N. Danforth, ScD, MPH

Funding Source:

Agency for Healthcare Research and Quality (AHRQ)

Funding Years:

2015 - 2018

Kidney Function Decline in Patients with CKD and Untreated Hepatitis C Infection

Studies evaluating the role of hepatitis C viral (HCV) infection on the progression of CKD are few and conflicting. Therefore, we evaluated the association of untreated HCV on kidney function decline in patients with stage 3-5 CKD.

Principal Investigator:

Sara Yee Tartof, PhD, MPH

Funding Source:

Merck & Co., Inc.

Funding Years:

2014 - 2017

Population-based diabetes in youth registry: SEARCH for Diabetes in Youth, Phase 4, California Site

The aims of this study are (1) to ascertain prevalent diabetes cases in calendar year 2017 among youth age <20 years at diagnosis, using cost-efficient approaches that maximize use of information in the electronic health records (EHRs) and administrative databases, (2) to continue to ascertain newly diagnosed (incident 2015-2020) diabetes cases in youth age <20 years, using cost-efficient approaches that maximize use of EHRs and administrative databases, (3) to determine agreement between the etiological classification of diabetes type using biochemical markers and provider assessment; to describe selected clinical characteristics at diagnosis, and to establish an infrastructure that facilitates the development of more detailed ancillary studies by storing biological samples and preserving contact with potential study participants, and (4) To optimize efficiency of SEARCH surveillance activities through targeted Development and Validation (D&V) Projects designed to utilize electronic health data to operationalize each of the three tiers of surveillance to the extent possible. (1U18 DP006133)

Principal Investigator:

Jean M. Lawrence, ScD, MPH, MSSA

Funding Source:

Centers for Disease Control and Prevention (CDC)

Funding Years:

2015 - 2020

Transition of Care in CKD (TC-CKD)

The proposed research project aims to examine how the best transition to dialysis treatment or kidney transplantation should happen in people who have very-late-stage chronic kidney disease in order to have the best survival, fewer hospitalizations and reduced costs. We will also study if the decision about earlier or later start of dialysis or about the type of dialysis or transplant can be determined from patient conditions before the transition, such as patient age, blood pressure or diabetes control, and speed of kidney disease progression.

Principal Investigator:

Steven J. Jacobsen, MD, PhD

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Funding Years:

2014