Genetics studies

Advances in genetic technologies and methodologies continue to help researchers learn more about the role that genetics and the environment play in disease and health. Our scientists collaborate with outside investigators to study the genetic effect, the gene-by-gene interaction, and the gene-environment interaction on the risk for various diseases. We participated in the development of the Kaiser Permanente Research Bank, a bank of biospecimen samples of several hundred thousand volunteers. This large-scale collection of genetic, environmental, and health information will be of immense value in conducting cutting-edge research.

Genetics of Beta Cell Failure in Mexican Americans: Phase II (Beta Gene II)

This application is proposed to call back ~400 individuals in our previous cross-sectional BetaGene cohort study (NIDDK 61628) and re-test them for phenotypes. Analysis will be conducted to determine which genes and how they interact with each other to impact the longitudinal changes in beta-cell function and other T2DM related traits.

Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institutes of Health (NIH)

Funding Years:

2009 - 2014

Observational Study of the Epidemiology in Clinical Outcomes of Breast Cancer in Women with BRCA Mutations

This cohort study examines the long-term clinical outcomes of women with breast cancer who are BRCA mutation carriers.

Principal Investigator:

Reina Haque, PhD, MPH

Funding Source:

AstraZeneca

Funding Years:

2015

Physiologic Consequence of Genetic Variation (BetaGene III)

The over-arching goal of this study is to assess the physiologic effect of genetic variation in humans and determine how variation in genes alters physiologic processes to contribute to diabetes pathogenesis.

Site Principal Investigator:

Anny Hui Xiang, PhD, MS

Funding Source:

National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS (NIDDK)

Funding Years:

2015